Autoimmune diseases in Turner syndrome: an overview

Autoimmune diseases in Turner syndrome: an overview

Authors

  • Vincenzo De Sanctis Quisisana Hospital, Ferrara
  • Doaa Khater Department of Paediatrics, Endocrinology Unit, Alexandria University Children's Hospital, Egypt and Child Health Department, Sultan Qaboos University Hospital, Muscat, Sultanate of Oman.

Keywords:

Turner syndrome, autoimmune disorders, pathophysiologic mechanisms, clinical characteristics

Abstract

Turner syndrome (TS) results from a sex-chromosomal anomaly characterized by presence of one normal X chromosome and the loss of the second X-chromosome in phenotypic females. Autoimmunity has been recognized as one of the more prominent characteristics of TS. The risk of autoimmune diseases in patients with TS is approximately twice as high as in the general female population. The spectrum includes, Hashimoto’s thyroiditis, coeliac disease (CD), type 1 diabetes (T1DM), alopecia areata, inflammatory bowel disease, juvenile rheumatoid arthritis and some cutaneous disorders as vitiligo and Halo nevus. This review will address the autoimmune disorders associated with TS, their pathophysiologic mechanisms and clinical characteristics.

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Published

06-09-2019

Issue

Section

PEDIATRIC AND ADOLESCENT ENDOCRINOLOGY UPDATE

How to Cite

1.
De Sanctis V, Khater D. Autoimmune diseases in Turner syndrome: an overview. Acta Biomed [Internet]. 2019 Sep. 6 [cited 2024 Jul. 13];90(3):341-4. Available from: https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/8737