Mendelian non-syndromic obesity

Mendelian non-syndromic obesity

Authors

  • Stefano Paolacci MAGI'S LAB
  • Giuseppe Pompucci Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy
  • Barbara Paolini Department of Dietetics and Clinical Nutrition, Azienda Ospedaliera Universitaria Senese, Policlinico Santa Maria alle Scotte, Siena, Italy
  • Irene Del Ciondolo Department of Dietetics and Clinical Nutrition, Azienda Ospedaliera Universitaria Senese, Policlinico Santa Maria alle Scotte, Siena, Italy
  • Giacinto Abele Donato Miggiano UOC Nutrizione Clinica, Fondazione Policlinico Universitario A. Gemelli IRCCS; Centro di Ricerche in Nutrizione Umana, Università Cattolica S. Cuore, Rome, Italy
  • Barbara Aquilanti UOC Nutrizione Clinica, Fondazione Policlinico Universitario A. Gemelli IRCCS
  • Andrea Scaramuzza Department of Pediatrics, Ospedale Maggiore di Cremona, Cremona, Italy
  • Valeria Velluti UOC Nutrizione Clinica, Fondazione Policlinico Universitario A. Gemelli IRCCS
  • Giuseppina Matera UOC Nutrizione Clinica, Fondazione Policlinico Universitario A. Gemelli IRCCS
  • Lucilla Gagliardi UOC Nutrizione Clinica, Fondazione Policlinico Universitario A. Gemelli IRCCS
  • Matteo Bertelli MAGI Euregio, Bolzano, Italy

Keywords:

Mendelian obesity, leptin/melanocortin pathway, adipogenesis

Abstract

Obesity is highly heritable and arises from the interplay of many genes and environmental factors. It can be defined as the result of prolonged imbalance between calorie intake and energy utilization. About 5% of cases of non-syndromic obesity are monogenic (Mendelian obesity). The amount of adipose tissue in the body is mainly regulated by leptin, a hormone produced by adipocytes, and Mendelian obesity is mainly caused by mutations that disrupt the leptin/melanocortin pathway. In this article, we summarize the genes involved in genetic obesity and the test we use for genetic analysis.

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Published

30-09-2019

How to Cite

1.
Mendelian non-syndromic obesity. Acta Biomed [Internet]. 2019 Sep. 30 [cited 2024 Mar. 29];90(10-S):87-9. Available from: https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/8766