The impact of MicroRNAs (miRNAs) on the genotype of coronaviruses

The impact of MicroRNAs (miRNAs) on the genotype of coronaviruses


  • Duran Canatan Prof. Dr. Duran Canatan MD Antalya Genetic Diseases Diagnosis Center Arapsuyu Mh. 600 Sk 39/A 07070 Konyaalti, Antalya,Turkey
  • Vincenzo De Sanctis [email protected]


MicroRNAs, Coronaviruses, genome, impacts


Summar y. The beginning of 2020 has seen the emergence of COVID-19, an outbreak caused by a novel

coronavirus, SARS-CoV-2, an important pathogen for humans. SARS-CoV-2 is an RNA virus containing 29891 nucleotides encoding 9889 amino acids. The genome is arranged as 5p-replicase (orf1/ab)-structural proteins [Spike (S) -Envelope (E) - Membrane (M) -Nucleocapsid (N)] −3. Viruses are obligate intracellular infectious agents that use the host cellular machinery to ensure their own fitness and survival. MicroRNAs (miRNA9) systems are potent post-transcriptional gene expression regulators that are important modulators of viral infections, and could play an important role in the treatment of viral infections. This review focuses to the genomic structure of coronaviruses, the functions of genomic proteins, the effects of micro RNA (miRNA) on virus replication and its pathogenesis.


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How to Cite

Canatan D, De Sanctis V. The impact of MicroRNAs (miRNAs) on the genotype of coronaviruses. Acta Biomed [Internet]. 2020 May 11 [cited 2024 Jul. 23];91(2):195-8. Available from: