What happens to people's lungs when they get coronavirus disease 2019?

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Annalisa Frizzelli
Domenico Tuttolomondo
Marina Aiello
Maria Majori
Giuseppina Bertorelli
Alfredo Chetta


SARS-CoV-2, Pneumonia, Respiratory failure, ARDS


The novel coronavirus SARS-CoV-2 was first identified in Wuhan in December 2019 as cause of the consequent novel coronavirus disease 2019 (COVID-19). The virus has since spread worldwide. The clinical presentation following human infection ranges from a mild upper respiratory tract infection to severe acute respiratory distress syndrome and sepsis. We reviewed literature using Pubmed to identify relevant English-language articles published until April 15, 2020. Search terms include novel coronavirus pneumonia, severe acute respiratory syndrome coronavirus 2, coronavirus and ventilation. We summarized what SARS-CoV-2 infection means for the lungs.


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