Cribiform-morular variant of papillary thyroid carcinoma and familial adenomatous polyposis: Report of a case

Cribiform-morular variant of papillary thyroid carcinoma and familial adenomatous polyposis: Report of a case

Authors

  • Mario Giuffrida General Surgery Unit, Parma University Hospital, Italy
  • Federica De Giorgi Department of Human Histopathology, Parma University Hospital, Parma
  • Federico Cozzani General Surgery Unit, Parma University Hospital, Italy
  • Matteo Rossini General Surgery Unit, Parma University Hospital, Italy
  • Elena Bonati General Surgery Unit, Parma University Hospital, Italy
  • Paolo Del Rio General Surgery Unit, Parma University Hospital, Italy

Keywords:

familial adenomatous polyposis, papillary thyroid carcinoma, FAP, thyroid

Abstract

Cribiform-morular thyroid carcinoma is a rare variant of papillary thyroid carcinoma. It is usually related to Familial Adenomatous Polyposis (FAP) but rarely it may be sporadic. This variant of PTC occurs in young females and it is rare in the elderly. We report a case of a 20 years old female presenting thyroid carcinoma and personal history of FAP.

References

Harach HR, Williams GT, Williams ED. Familial adenomatous polyposis associated thyroid carcinoma: a distinct type of follicular cell neoplasm. Histopathology, 1994, 25(6):549–561.

Cameselle-Teijeiro J, Chan JK. Cribriform-morular variant of papillary carcinoma: a distinctive variant representing the sporadic counterpart of familial adenomatous polyposis-associated thyroid carcinoma? Mod Pathol, 1999, 12(4):400–411.

Cameselle-Teijeiro J, Ruiz-Ponte C, Loidi L, Suarez-Peñaranda J, Baltar J, Sobrinho-Simoes M. Somatic but not germline mutation of the APC gene in a case of cribriformmorular variant of papillary thyroid carcinoma. Am J Clin Pathol, 2001, 115(4):486–493.

Rohaizak M, Jasmi AY, Ismail MA, Munchar MJ, Meah FA. Thyroid carcinoma in patient with familial adenomatous polyposis. Asian J Surg. 2003;26(3):183–185. doi: 10.1016/S1015-9584(09)60381–X .

Hogan AR, Zhuge Y, Perez EA, Koniaris LG, Lew JI, Sola JE. Pediatric thyroid carcinoma: incidence and outcomes in 1753 patients. J Surg Res, 2009, 156(1):167–172.

Yip FW, Reeve TS, Poole AG, Delbridge L. Thyroid nodules in childhood and adolescence. Aust N Z J Surg, 1994, 64(10): 676–678

Cameselle-Teijeiro J, Menasce LP, Yap BK, Colaco RJ, Castro P, Celestino R, Ruíz-Ponte C, Soares P, SobrinhoSimões M. Cribriform-morular variant of papillary thyroid carcinoma: molecular characterization of a case with neuroendocrine differentiation and aggressive behavior. Am J Clin Pathol, 2009, 131(1):134–142.

Soravia C, Sugg SL, Berk T, Mitri A, Cheng H, Gallinger S, et al. Familial adenomatous polyposis-associated thyroid cancer: A clinical, pathological, and molecular genetics study. Am J Pathol. 1999;154(1):127–135.

Anaya DA, Chang GJ, Rodriguez-Bigas MA. Extracolonic manifestations of hereditary colorectal cancer syndromes. Clin Colon Rectal Surg. 2008;21(4):263–272. doi:10.1055/s-0028-1089941

Talbot IC, Burt R, Järvinen H. Familial adenomatous polyposis. In: Hamilton SR, Aaltonen LA (eds). Pathology and genetics of tumours of the digestive system. WHO International Classification of Tumours, IARC Press, Lyon, France, 2000, 120–125.

Hizawa K, Iida M, Aoyagi K, Yao T, Fujishima M. Thyroid neoplasia and familial adenomatous polyposis/Gardner’s syndrome. J Gastroenterol. 1997;32(2):196–199. doi: 10.1007/BF02936367 .

Truta B, Allen BA, Conrad PG, Kim YS, Berk T, Gallinger S,vBapat B, Terdiman JP, Sleisenger MH. Genotype and phenotype of patients with both familial adenomatous polyposis andvthyroid carcinoma. Fam Cancer, 2003, 2(2):95–99

Herraiz M, Barbesino G, Faquin W, Chan-Smutko G, Patel D, Shannon KM, Daniels GH, Chung DC. Prevalence of thyroid cancer in familial adenomatous polyposis syndrome and the role of screening ultrasound examinations. Clin Gastroenterol Hepatol, 2007, 5(3):367–373.

Cetta F, Pelizzo MR, Curia MC, Barbarisi A. Genetics and clinicopathological findings in thyroid carcinomas associated with familial adenomatous polyposis. Am J Pathol, 1999, 155(1):7–9.

Lee S, Hong SW, Shin SJ, Kim YM, Rhee Y, Jean BI, Moon WC, Oh MR, Lim SK. Papillary thyroid carcinoma associated with familial adenomatous polyposis: molecular analysis of pathogenesis in a family and review of the literature. Endocr J, 2004, 51(3):317–323

Chikkamuniyappa S, Jagirdar J. Cribriform-morular variant of papillary carcinoma: Association with familial adenomatous polyposis - report of three cases and review of literature. Int J Med Sci. 2004;1(1):43–49. doi: 10.7150/ijms.1.43 .

Inomata M, Ochiai A, Akimoto S, Kitano S, Hirohashi S: Alteration of beta-catenin expression in colonic epithelial cells of familial adenomatous polyposis patients. Cancer Res. 1996;56:2213–2217.

Sastre-Perona A, Santisteban P: Role of the Wnt pathway in thyroid cancer. Front Endocrin 2012;3:31.

Hirokawa M, Maekawa M, Kuma S, Miyauchi A. Cribriform-morular variant of papillary thyroid carcinoma–cytological and immunocytochemical findings of 18 cases. Diagn Cytopathol. 2010;38(12):890–896. doi: 10.1002/dc.21309.

Yim JH, Doherty GM. Papillary thyroid cancer. Curr Treat Options Oncol. 2000;1(4):329–338. doi: 10.1007/s11864-000-0048-3 .

Hildesheim J, Salvador JM, Hollander MC, Fornace AJ. Jr. Casein kinase 2- and protein kinase A-regulated adenomatous polyposis coli and beta-catenin cellular localization is dependent on p38 MAPK. J Boil Chem. 2005;280(17):17221–17226

Xu B, Yoshimoto K, Miyauchi A, et al. Cribriform-morular variant of papillary thyroid carcinoma: a pathological and molecular genetic study with evidence of frequent somatic mutations in exon3 of the β-catenin gene. J Pathol. 2003;199(1):58–67. doi: 10.1002/path.1225.

Francesco Cetta, Gabriele Ugolini, Leonardo Barellini, Serenella Civitelli, Mario Carmellini. FAP associated cribriform morular variant of PTC: Striking female prevalence and indolent course. Endocrine J. 2011;58(9):817–818.

Yasuhiro Ito, Akira Miyauchi, Hideki Ishikawa, Mitsuhiro Hirokawa, Takumi Kudo, Chisato Tomoda, et al. Our experience of treatment of cribriform-morular variant of papillary thyroid carcinoma; difference in clinicopathological features of FAP-associated and sporadic patients. Endocrine J. 2011;58(8):685–689.

Perrier ND, van Heerden JA, Goellner JR, et al. Thyroid cancer in patients with familial adenomatous polyposis. World J Surg. 1998;22:738–742. doi: 10.1007/s002689900462.

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Published

30-04-2021

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Section

Case Reports: Oncology and Hematology

How to Cite

1.
Giuffrida M, De Giorgi F, Cozzani F, Bonati E, Del Rio P. Cribiform-morular variant of papillary thyroid carcinoma and familial adenomatous polyposis: Report of a case. Acta Biomed [Internet]. 2021 Apr. 30 [cited 2024 Jul. 20];92(S1). Available from: https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/9691