An unusual aggressive presentation of late onset sepsis due to Staphylococcus aureus MRSA producing Panton-Valentine Leukocidin in preterm neonate: An unusual case of severe sepsis in preterm neonate

An unusual aggressive presentation of late onset sepsis due to Staphylococcus aureus MRSA producing Panton-Valentine Leukocidin in preterm neonate

An unusual case of severe sepsis in preterm neonate

Authors

  • Letizia Capasso Neonatology, Pediatrics. Departement of Translational Medical Science. University Federico II, Napoli, Italy.
  • Julia Cerullo Neonatology, Pediatrics. Departement of Translational Medical Science. University Federico II, Napoli, Italy
  • Andrea Lo Vecchio Pediatric Infectious Diseases Unit. Departement of Translational Medical Science. University Federico II, Napoli, Italy.
  • Clara Coppola Neonatology, Pediatrics. Departement of Translational Medical Science. University Federico II, Napoli, Italy
  • Lorenza Lepore Neonatology, Pediatrics. Departement of Translational Medical Science. University Federico II, Napoli. Italy
  • Valentina Marra Neonatology, Pediatrics. Departement of Translational Medical Science. University Federico II, Via Pansini 5, 80131. Napoli. Italy
  • Eleni Antonaki Department of Molecular Medicine and Medical Biotechnology - Division of Bacteriology and Mycology, University of Naples. Federico II, Naples, Italy
  • Francesco Raimondi Neonatology, Pediatrics. Departement of Translational Medical Science. University Federico II, Napoli. Italy

Keywords:

methicillin resistant Staphylococcus aureus,, neonate,, Panton-Valentine leukocidin,, late onset sepsis,, case report

Abstract

We report an unusual and rare case of infection from methicillin resistant Staphylococcus aureus (MRSA) producing Panton-Valentine leukocidin in a preterm neonate in NICU. On day of life 8, a preterm baby boy suddenly developed arthritis, giant cutaneous abscesses and an osteomyelitic focus with pour clinical condition. This very aggressive presentation of infection from MRSA push us to test Panton-Valentine leukocidin resulted positive and to test contacts to discover the bearer of the germ. MRSA producing Panton-Valentine leukocidin is an unusual case of infection in preterm neonate that has not been reported elsewhere. A very aggressive sepsis in neonates from Staphilococcus aureus should evoke the need to test Panton-Valentine leukocidin to rapidly establish an appropriate treatment. We underline also the importance to test contacts to establish promptly a decontaminant therapy

References

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Published

30-04-2021

Issue

Section

Case Reports: Pediatrics and Neonatology

How to Cite

1.
Capasso L, Cerullo J, Lo Vecchio A, Coppola C, Lepore L, Marra V, et al. An unusual aggressive presentation of late onset sepsis due to Staphylococcus aureus MRSA producing Panton-Valentine Leukocidin in preterm neonate: An unusual case of severe sepsis in preterm neonate. Acta Biomed [Internet]. 2021 Apr. 30 [cited 2024 Jul. 24];92(S1):e2021147. Available from: https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/9885