An unusual aggressive presentation of late onset sepsis due to Staphylococcus aureus MRSA producing Panton-Valentine Leukocidin in preterm neonate
An unusual case of severe sepsis in preterm neonate
Keywords:
methicillin resistant Staphylococcus aureus,, neonate,, Panton-Valentine leukocidin,, late onset sepsis,, case reportAbstract
We report an unusual and rare case of infection from methicillin resistant Staphylococcus aureus (MRSA) producing Panton-Valentine leukocidin in a preterm neonate in NICU. On day of life 8, a preterm baby boy suddenly developed arthritis, giant cutaneous abscesses and an osteomyelitic focus with pour clinical condition. This very aggressive presentation of infection from MRSA push us to test Panton-Valentine leukocidin resulted positive and to test contacts to discover the bearer of the germ. MRSA producing Panton-Valentine leukocidin is an unusual case of infection in preterm neonate that has not been reported elsewhere. A very aggressive sepsis in neonates from Staphilococcus aureus should evoke the need to test Panton-Valentine leukocidin to rapidly establish an appropriate treatment. We underline also the importance to test contacts to establish promptly a decontaminant therapy
References
Capasso L, Borrelli AC, Ferrara T, Coppola C, Cerullo J, Izzo F, Caiazza R, Lama S, Raimondi F. Immunoglobulins in neonatal sepsis: has the final word been said? Early Hum Dev. 2014 Sep;90 Suppl 2:S47-9. doi: 10.1016/S0378-3782(14)50013-8. Review.
Vanhecke C, Girerd R, Dujardin M, Zemali N, Manaquin R, Duport P, Traversier N, Mougin-Damour K, Vandroux D. Retrospective study of pneumonia due to Panton-Valentine leukocidin-producing Staphylococcus aureus in Reunion. Med Mal Infect. 2019 Oct;49(7):534-539
Leistner R, Kola A, Gastmeier P, Krüger R, Hoppe PA, Schneider-Burrus S, Zuschneid I, Wischnewski N, Bender J, Layer F, Niebank M, Scheibenbogen C, Hanitsch LG. Pyoderma outbreak among kindergarten families: Association with a Panton-Valentine leukocidin (PVL)-producing S. aureus strain. PLoS One. 2017 Dec 19;12(12):e0189961
Del Vecchio A, Ferrara T, Maglione M, Capasso L, Raimondi F. New perspectives in Respiratory Syncitial Virus infection. J Matern Fetal Neonatal Med. 2013 Oct;26 Suppl 2:55-9. doi: 10.3109/14767058.2013.831282
Khattak SG, Dady I, Mukherjee 1. Unusual presentation of late-onset disseminated staphylococcal sepsis in a preterm infant. BMJ Case Rep. 2019 Mar 15;12(3). pii: e226325. doi: 10.1136/bcr-2018-226325.
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