Negative nasopharyngeal swabs in COVID-19 pneumonia: the experience of an Italian Emergengy Department (Piacenza) during the first month of the Italian epidemic

Negative nasopharyngeal swabs in COVID-19 pneumonia: the experience of an Italian Emergengy Department (Piacenza) during the first month of the Italian epidemic

Authors

  • Erika Poggiali a:1:{s:5:"en_US";s:69:"Ospedale Guglielmo da Saliceto, Emergency Department, Piacenza, Italy";}
  • Andrea Vercelli Emergency Department, “Guglielmo da Saliceto” Hospital, Piacenza, Italy Via Giuseppe Taverna 49, Piacenza, Italy.
  • Giovanni Battista Vadacca Biochemestry Unit, Clinical Pathology Department, “Guglielmo da Saliceto” Hospital, Via Giuseppe Taverna 49, Piacenza, Italy.
  • Roberta Schiavo Microbiology Unit, Clinical Pathology Department, “Guglielmo da Saliceto” Hospital, Via Giuseppe Taverna 49, Piacenza, Italy.
  • Silvana Mazzoni Emergency Department, “Guglielmo da Saliceto” Hospital, Piacenza, Italy Via Giuseppe Taverna 49, Piacenza, Italy.
  • Eva Ioannilli Emergency Department, “Guglielmo da Saliceto” Hospital, Piacenza, Italy Via Giuseppe Taverna 49, Piacenza, Italy.
  • Elena Demichele Emergency Department, “Guglielmo da Saliceto” Hospital, Piacenza, Italy Via Giuseppe Taverna 49, Piacenza, Italy.
  • Andrea Magnacavallo Emergency Department, “Guglielmo da Saliceto” Hospital, Piacenza, Italy Via Giuseppe Taverna 49, Piacenza, Italy.

Keywords:

COVID-19, nasopharyngeal swab, RT-PCR, serology, Italian epidemic

Abstract

Coronavirus disease (COVID-19) is a systemic disease which can cause multiple organ failure and death primarly due to vascular endothelium injury. Severe acute respiratory distress syndrome (ARDS) is the main cause of death: its management and treatment should be tailored to the individual COVID-19 patient’s phenotype. Early diagnosis of COVID-19 is paramount for disease treatment and infection control. Naso-pharyngeal (NP) swab is commonly used as screening and diagnostic tool for COVID-19, but in some cases it can be resulted negative even in presence of clinical and epidemiological criteria, and typical radiological and laboratory findings of COVID-19, as we have observed. Here we report our experience in the first month of the Italian epidemic. We strongly recommend clinicians to maintain a high index of suspicion for COVID-19, regardless of the persistence negativity of NP swabs, and not to delay the initiation of therapy in presence of typical clinical, radiological and laboratory findings of COVID-19. 

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Published

07-09-2020

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REVIEWS/FOCUS ON - SPECIAL COVID19

How to Cite

1.
Negative nasopharyngeal swabs in COVID-19 pneumonia: the experience of an Italian Emergengy Department (Piacenza) during the first month of the Italian epidemic. Acta Biomed [Internet]. 2020 Sep. 7 [cited 2024 Apr. 16];91(3):e2020024. Available from: https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/9979

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