Effect of Thrombin Activation on Vascular Endothelial Growth Factor Levels in Platelet-Rich Plasma Prepared with Different Anticoagulants

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Effect of Thrombin Activation on Vascular Endothelial Growth Factor Levels in Platelet-Rich Plasma Prepared with Different Anticoagulants

Authors

  • Lara Laura Pratiwi Murad Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
  • Uleng Bahrun Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University – Dr. Wahidin Sudirohusodo Hospital, Makassar, Indonesia https://orcid.org/0000-0002-8284-5351
  • Mansyur Arif Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University – Dr. Wahidin Sudirohusodo Hospital, Makassar, Indonesia https://orcid.org/0009-0000-5894-4977
  • Agus Alim Abdullah Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University – Dr. Wahidin Sudirohusodo Hospital, Makassar, Indonesia https://orcid.org/0009-0000-6242-8705
  • Yuyun Widaningsih Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University – Dr. Wahidin Sudirohusodo Hospital, Makassar, Indonesia https://orcid.org/0009-0008-9058-4244

Keywords:

Platelet-Rich Plasma, Vascular Endothelial Growth Factors, Thrombin, Anticoagulants, Citrates

References

1. Pretorius J, Habash M, Ghobrial B, Alnajjar R, Ellanti P. Current Status and Advancements in Platelet-Rich Plasma Therapy. Cureus. 2023;15(10):1-12. doi:10.7759/cureus.47176

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3. Wu WS, Chen LR, Chen KH. Platelet-Rich Plasma (PRP): Molecular Mechanisms, Actions and Clinical Applications in Human Body. Int J Mol Sci. 2025;26(21):1-36. doi:10.3390/ijms262110804

4. Sjöbom U, Nilsson AK, Gyllensten H, Hellström A, Löfqvist C. A systematic review and meta-analysis of preanalytical factors and methodological differences influencing the measurement of circulating vascular endothelial growth factor. Glading AJ, ed. PLoS ONE. 2022;17(7):1-31. doi:10.1371/journal.pone.0270232

5. Schlingemann RO, Van Noorden CJF, Diekman MJM, et al. VEGF Levels in Plasma in Relation to Platelet Activation, Glycemic Control, and Microvascular Complications in Type 1 Diabetes. Diabetes Care. 2013;36(6):1629-1634. doi:10.2337/dc12-1951

6. Giannelli A, Forte M, D’Albis G, et al. Utilization of Platelet-Rich Plasma in Oral Surgery: A Systematic Review of the Literature. JCM. 2025;14(8):1-14. doi:10.3390/jcm14082844

How to Cite

1.
Murad LLP, Bahrun U, Arif M, Abdullah AA, Widaningsih Y. Effect of Thrombin Activation on Vascular Endothelial Growth Factor Levels in Platelet-Rich Plasma Prepared with Different Anticoagulants. Acta Biomed. 97:19172. doi:10.23750/abm.2026.19172

Issue

Vol. 97 (2026): ONLINE FIRST - Acta Biomedica 2026; volume 97

Section

LETTERS TO THE EDITOR AND CORRESPONDENCE
DOI: https://doi.org/10.23750/abm.2026.19172

License

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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How to Cite

1.
Murad LLP, Bahrun U, Arif M, Abdullah AA, Widaningsih Y. Effect of Thrombin Activation on Vascular Endothelial Growth Factor Levels in Platelet-Rich Plasma Prepared with Different Anticoagulants. Acta Biomed. 97:19172. doi:10.23750/abm.2026.19172
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