Isolated optic nerve sarcoidosis

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Sandip Suresh
Gregory S Kosmorsky
Michael S Lee


Sarcoidosis, Optic nerve, Optic neuritis, Optic neuropathy


Objective: To report three cases of sarcoidosis confined to the optic nerve.

Methods: Chart review of clinical, laboratory, imaging, and optic nerve biopsy findings and a review of the literature.

Results: All three cases presented with progressive visual loss and showed enhancement of the intraorbital optic nerve on magnetic resonance imaging. There was no evidence for systemic disease, including a negative workup for sarcoidosis or other infiltrative pathologies. Optic nerve biopsy in each case showed non-caseating granulomas consistent with sarcoidosis.

Conclusions: Sarcoidosis confined to the optic nerve is a rare phenomenon but should still be considered in the differential diagnosis of progressive optic neuropathy, even in the absence of systemic disease. 

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