Serum amyloid A in lung transplantation

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Lucia Vietri
Elena Bargagli
David Bennett
Antonella Fossi
Paolo Cameli
Laura Bergantini
Miriana d’Alessandro
Piero Paladini
Luca Luzzi
Francesco Gentili
Maria Antonietta Mazzei
Donatella Spina
Piersante Sestini
Paola Rottoli

Keywords

serum amyloid A, serum biomarkers, lung transplantation

Abstract

Background: Serum Amyloid A (SAA) is an acute phase protein and we analyzed its concentrations in lung transplantated patients (LTX). Methods: 26 LTX patients (58.6 ± 11 years) and 11 healthy controls (55 ± 11.3 years). Three groups of LTX patients: acute rejection (AR, 7) bronchiolitis obliterans syndrome (BOS, 3), acute infection (INF, 9) and stable patients (NEG, 7). Results: In LTX patients SAA concentrations were significantly increased, particularly in AR and INF. In LTX-AR patients were observed a correlation between SAA levels and peripheral CD4+ lymphocyte percentage (r=0.9, p<0.01) and a reverse correlation with FVC percentages (r -0.94, p=0.01). Conclusions: SAA may represent a potential biomarker of LTX acute complications, with a prognostic value in AR. 

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