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platelet-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio, acute/chronic hypersensitivity pneumonia
Aim: To evaluate Platelet-to-Lymphocyte Ratio (PLR) and Neutrophil-to-Lymphocyte Ratio (NLR) in patients with HP.
Method: A sample of 140 total patients, 50 having chronic HP and 20 having acute HP, and a control group of 70 more patients were included in this retrospective study conducted with hospital Ethical Committee approval.
Results: PLR and NLR values were significantly higher in all HP patients than in the control group ( p <0.001). In addition, these biomarkers were significantly higher in patients with acute HP than in the chronic HP group (p = 0.017 and p = 0.044, respectively). The cutoff values for PLR and NLR were:
- 177 (p = 0.020) and 2.76 (p <0.0001) between the HP patients and the control group, and,
- 110 (p = 0.0054) and 2.15 (p = 0.03), between the acute and chronic HP groups.
Conclusion: PLR and NLR values are inexpensive and easy parameters that can guide in diagnosing hypersensitivity pneumonia and the acute-chronic differentiation of the disease.