Basics in Magnetic Resonance guided Focused Ultrasound: technical basis and clinical application. A brief overview

Basics in Magnetic Resonance guided Focused Ultrasound: technical basis and clinical application. A brief overview


  • Pierpaolo Palumbo Department of Diagnostic Imaging, area of Cardiovascular and Interventional Imaging, Abruzzo Health Unit 1, Italy and Italian Society of Medical and Interventional Radiology (SIRM), SIRM Foundation, Milan, Italy
  • Julia Daffinà Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, L’Aquila, Italy
  • Federico Bruno Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, L’Aquila, Italy and Italian Society of Medical and Interventional Radiology (SIRM), SIRM Foundation, Milan, Italy
  • Francesco Arrigoni Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, L’Aquila, Italy
  • Alessandra Splendiani Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, L’Aquila, Italy
  • Ernesto Di Cesare Department of Clinical Medicine, Public Health, Life and Environmental Science, University of L’Aquila, L’Aquila, Italy
  • Antonio Barile Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, L’Aquila, Italy
  • Carlo Masciocchi Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, L’Aquila, Italy


MRgFUS, HIFU, Magnetic Resonance guided focused ultrasound, clinical application, physics


First applications of high focused ultrasound as intracranial ablative therapy were firstly described in early 50’. Since then, the technological innovations have shown an increasingly safe and effective face of this technique. And in the last few years, Magnetic Resonance (MR) guided Focused Ultrasound (gFUS) has become a valid minimally invasive technique in the treatment of several diseases, from bone tumors to symptomatic uterine fibroids or essential tremors.

MR guidance, through the tomographic view, offers the advantage of an accurate target detection and treatment planning. Moreover, real-time monitoring sequences allow to avoid non-target ablation.

An adequate knowledge of FUS is essential to understand its clinical effectiveness. Therefore, this brief review aims to debate the physical characteristics of US and the main fields of clinical application.


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Basics in Magnetic Resonance guided Focused Ultrasound: technical basis and clinical application. A brief overview. Acta Biomed [Internet]. 2021 Sep. 10 [cited 2024 Jun. 23];92(S5):e2021403. Available from: