Vanilloid-mediated apoptosis in prostate cancer cells through aTRPV-1 dependent and a TRPV-1-independent mechanism

Main Article Content

F. Ziglioli
A. Frattini
U. Maestroni
F. Dinale, et al.


Vanilloid, capsaicin, prostate cancer, apoptosis, TRPV-1


Vanilloids are natural molecules identified in a plethora of foods normally ingested through the diet. They mediate apoptosis through a direct pathway (independent of TRPV-1, the receptor for vanilloids) and through an indirect pathway, i.e. thanks to the interaction with TRPV-1 and the successive intracellular calcium growth [Ca2+]i. Some vanilloids, such as capsaicin, dihydrocapsaicin and resiniferatoxin (the ultrapotent analogue of capsaicin, extractable from Euphorbia resinifera), may be considered as coenzyme Q antagonists: in fact, they inhibit the run of the electrons through the electron transport chain, so determining an excess of reactive oxygen species (ROS). A second effect of the interaction between the vanilloids and
TRPV-1 receptor may be reported: it is the fast decrease of the transmembrane mitochondrial potential (ΔΨm). Through the direct pathway, on the contrary, the vanilloids induce apoptosis also interacting with caspases, particularly caspase 1 and 3. On the whole, the vanilloids are able to lead to the intracellular calcium growth and consequently to the evidence of precocious and late elements of apoptosis.


Download data is not yet available.
Abstract 88 | PDF Downloads 55