Insulin resistance and secrection indexes in healthy Italian childrenand adolescents: a multicentre study

Insulin resistance and secrection indexes in healthy Italian childrenand adolescents: a multicentre study

Authors

  • G. d'Annunzio
  • M. Vanelli
  • A. Pistorio
  • N. Minuto, et al.

Keywords:

Insulin resistance, HOmeostatic Model Assessment (HOMA), QUantitative Insulin-sensitivity ChecK Index (QUICKI), paradigm model, minimal model, type 2 diabetes mellitus, obesity

Abstract

Background and aim: To establish normal values of insulin resistance, secretion and sensitivity using respectively HOMA-IR, HOMA-β% and QUICKI indexes in healthy Italian children and adolescents, based on fasting samples. Methods: We determined HOMA-IR, HOMA-β% and QUICKI at baseline in 142 healthy subjects from Pediatric Centres, aged 2.7 to 19 years (10.6±3.8, Mean±SD), with different Tanner’s pubertal Stages (TS). None had hypo/hyperglycemia (fasting plasma glucose ranging from 3.6 to 5.6 mmol/l), obesity (BMI (kg/m2) 17.9±2.4, M±SD), or family history for diabetes mellitus. Results: The HOMA-IR index slightly increases with Tanner’s stage. As regards HOMA-β% and QUICKI, a weak variation throughout puberty was observed. No significant correlation was observed between HOMA-IR, HOMA-β%, QUICKI and BMI-SDS or chronologic age. Conclusions: Normal values of HOMA-IR, HOMA-β% and QUICKI are useful tools in the clinical and epidemiological practice for baseline screening and follow-up of subjects at risk for type 2 diabetes mellitus.

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Published

01-04-2009

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Section

ORIGINAL ARTICLES

How to Cite

1.
Insulin resistance and secrection indexes in healthy Italian childrenand adolescents: a multicentre study. Acta Biomed [Internet]. 2009 Apr. 1 [cited 2024 May 19];80(1):21-8. Available from: https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/1232

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