Clinical evaluation of topical tacalcitol efficacy in extending theremission period between nb-UVB phototherapy cycles in psoriaticpatients

Clinical evaluation of topical tacalcitol efficacy in extending theremission period between nb-UVB phototherapy cycles in psoriaticpatients

Authors

  • F. Prignaro
  • G. Buggiani
  • T. Lotti

Keywords:

Psoriasis, tacalcitol, phototherapy

Abstract

Psoriasis is a very common dermatological disease affecting a large part of the world population. In its most common form, psoriasis vulgaris, many topical drugs are available to treat the localized forms, and the recurrence of the dermatosis. Among topicals, tacalcitol has been proven to be effective and devoid of side effects which are typical of Vitamin-D3 analogues or derivates. The aim of this retrospective study was to evaluate the efficacy of topical tacalcitol vs calcipotriol and emollient treatment of the first recurring lesion in order to induce a longer remission period before the retreatment with nb-UVB phototherapy in a population of 90 psoriatic patients. In this trial, the time between the first relapsing plaque appearance and retreatment with nb-UVB resulted in 25, 16 and 11 days for tacalcitol, calcipotriol and emollient respectively, with a statistically significant difference for tacalcitol (p<0.0001). These results proved that tacalcitol treatment is effective in increasing the time interval in consecutive phototherapy cycles and in reducing the total amount of UV exposure.

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Published

01-04-2009

Issue

Section

ORIGINAL ARTICLES

How to Cite

1.
Clinical evaluation of topical tacalcitol efficacy in extending theremission period between nb-UVB phototherapy cycles in psoriaticpatients. Acta Biomed [Internet]. 2009 Apr. 1 [cited 2024 Jun. 21];80(1):51-6. Available from: https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/1237