Burning mouth syndrome and oral microbiota: a review

Burning mouth syndrome and oral microbiota: a review

Authors

  • Michele Russo 1Anesthesiology, Critical Care and Pain Medicine Division, Department of Medicine and Surgery, University of Parma, Parma, Italy
  • Pellegrino Crafa
  • Lorella Franzoni Department of Medicine and Surgery, University of Parma
  • Marilisa Franceschi Endoscopy Unit, Department of Medicine, ULSS7 Pedemontana, Hospital AltoVicentino, Santorso (VI), Italy, Schio (Vi), IT
  • Kryssia Isabel Rodriguez-Castro Endoscopy Unit, Department of Medicine, ULSS7 Pedemontana, Hospital AltoVicentino, Santorso (VI), Italy, Schio (Vi), IT
  • Antonio Tursi Territorial Gastroenterology Service, Azienda Sanitaria Locale Barletta-Andria-Trani, Andria, Italy
  • Giovanni Brandimarte Division of Internal Medicine and Gastroenterology, Cristo Re Hospital, Rome, Italy
  • Francesco Di Mario Department of Medicine and Surgery, University of Parma

Keywords:

burning mouth syndrome, oral microbiota, oral bacteria

Abstract

Background and aim: Burning mouth syndrome (BMS) is a chronic condition characterized by intraoral burning or dysesthetic sensations without evident causative lesions. The etiology of BMS remains unclear, and effective treatments are lacking. This review aimed to evaluate the correlation between BMS and oral microbiota by analyzing relevant studies. Methods: A literature search was conducted in PubMed, Embase, and Scopus databases from inception until 11 june 2023. Results: Two studies were identified, providing preliminary evidence on this association. The first study compared the oral microbial profiles of patients with primary BMS and healthy controls, revealing lower microbial diversity in the BMS group and specific microbial taxa associated with BMS. The second study assessed the incidence of oral infections in BMS patients and their impact on symptoms, finding no significant correlation between oral infections and BMS symptoms. Conclusions: The findings suggest a potential association between oral microbiota and BMS, with alterations in the oral microbial community possibly contributing to BMS pathogenesis. Disease-specific microbial markers may have diagnostic implications for BMS. However, the limited number of studies and heterogeneity among them emphasize the need for further well-designed research employing larger sample sizes, standardized methodologies, and consistent diagnostic criteria.

Author Biography

Pellegrino Crafa

References

Kohorst JJ, Bruce AJ, Torgerson RR, Schenck LA, Davis MDP. The prevalence of burning mouth syndrome: a population-based study. Br J Dermatol 2015;172:1654-1656. doi:10.1111/bjd.13613

Bergdahl M, Bergdahl J. Burning mouth syndrome: prevalence and associated factors. J Oral Pathol Med 1999;28:350-354. doi:10.1111/j.1600-0714.1999.tb02052.x

Su NY, Wang YH, Chang YC. A nationwide register-based study of the prevalence of burning mouth syndrome in Taiwan from 2004 to 2013. J Dent Sci 2021;16:1074-1079. doi:10.1016/j.jds.2021.06.020

Wu S, Zhang W, Yan J, Noma N, Young A, Yan Z. Worldwide prevalence estimates of burning mouth syndrome: A systematic review and meta-analysis. Oral Dis 2021 Apr 5. doi:10.1111/odi.13868

Russo M, Crafa P, Guglielmetti S, Franzoni L, Fiore W, Di Mario F. Burning Mouth Syndrome Etiology: A Narrative Review. J Gastrointestin Liver Dis. 2022 Jun 12;31(2):223-228. doi: 10.15403/jgld-4245.

Sharon G, Sampson TR, Geschwind DH, Mazmanian SK. The Central Nervous System and the Gut Microbiome. Cell. 2016 Nov 3;167(4):915-932. doi: 10.1016/j.cell.2016.10.027.

Ding W, You Z, Chen Q, et al. Gut Microbiota Influences Neuropathic Pain Through Modulating Proinflammatory and Anti-inflammatory T Cells. Anesth Analg. 2021 Apr 1;132(4):1146-1155. doi:10.1213/ANE.0000000000005155.

Ding T, Schloss PD. Dynamics and associations of microbial community types across the human body. Nature. 2014 May 15;509(7500):357-60. doi: 10.1038/nature13178.

Cattaneo C, Gargari G, Koirala R, et al. New insights into the relationship between taste perception and oral microbiota composition. Sci Rep. 2019 Mar 5;9(1):3549. doi: 10.1038/s41598-019-40374-3.

Tuominen H, Rautava J. Oral Microbiota and Cancer Development. Pathobiology. 2021;88(2):116-126. doi: 10.1159/000510979.

Peng X, Cheng L, You Y, et al. Oral microbiota in human systematic diseases. Int J Oral Sci. 2022 Mar 2;14(1):14. doi: 10.1038/s41368-022-00163-7.

Al-Janabi AAHS. A Positive or Negative Connection of Diabetes Mellitus to the Oral Microbiota. Eurasian J Med. 2023 Feb;55(1):83-89. doi: 10.5152/eurasianjmed.2023.21164.

Silvestre FJ, Silvestre-Rangil J, López-Jornet P. Burning mouth syndrome: a review and update. Rev Neurol. 2015 May 16;60(10):457-63.

Lee BM, Park JW, Jo JH, Oh B, Chung G. Comparative analysis of the oral microbiome of burning mouth syndrome patients. J Oral Microbiol. 2022 Mar 20;14(1):2052632. doi: 10.1080/20002297.2022.2052632.

Jankovskis V, Selga G. Candidiasis and Other Bacterial Infections among Patients Diagnosed with Burning Mouth Syndrome. Medicina (Kaunas). 2022 Aug 1;58(8):1029. doi: 10.3390/medicina58081029.

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Published

28-02-2024

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Section

REVIEWS CLINICAL ARTICLES, UPDATES, FOCUS ON

How to Cite

1.
Burning mouth syndrome and oral microbiota: a review. Acta Biomed [Internet]. 2024 Feb. 28 [cited 2024 May 20];95(1):e2024004. Available from: https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/14950

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