Quality of life and functional disability in patients with interstitial lung disease related to Systemic Sclerosis

Quality of life and functional disability in patients with interstitial lung disease related to Systemic Sclerosis

Authors

  • Federica Lumetti Medicine Department, Internal Medicine and Rheumatology Unit, University Hospital, Parma, Italy
  • Lissette Barone Medicine Department, Internal Medicine and Rheumatology Unit, University Hospital, Parma, Italy
  • Cristina Alfieri Medicine Department, Internal Medicine and Rheumatology Unit, University Hospital, Parma, Italy
  • Mario Silva Department of Clinical Sciences, Section of Radiology, University of Parma, Italy
  • Valter Serra Cardiopulmonary Department, Cardiology Unit di Cardiology, University Hospital, Parma, Italy
  • Giovanni Delsante Medicine Department, Internal Medicine and Rheumatology Unit, University Hospital, Parma, Italy
  • Nicola Sverzellati Department of Clinical Sciences, Section of Radiology, University of Parma, Italy
  • Alarico Ariani Medicine Department, Internal Medicine and Rheumatology Unit, University Hospital, Parma, Italy

Keywords:

scleroderma, health related quality of life, interstitial lung disease, dyspnea

Abstract

Background: Systemic Sclerosis (SSc) is a connective disease impairing respiratory function. SSc worsens patients’ Health Assessment Questionnaire (HAQ-DI), Short Form 36 Physical and Mental Component Summary (SF36-PCS and SF36-MCS). The aim of this work is to verify whether there is correlation between quality of life and lung interstitiopathy in SSc patients. Methods: SF36 and HAQ-DI were given to each patient (48 in all). Lung involvement was evaluated with Baseline Dyspnea Index (BDI), spirometry and pulmonary fibrosis radiological assessment (PFRA). Correlations between SF36, HAQ-DI and lung involvement severity were investigated with Spearman’s rank test. A p-value<0.05 was considered statistically significant. Results: SF36-PCS and SF36-MCS correlate with BDI (respectively rho=0.553 p=0.0001; rho=0.357 p=0.0150). The best correlating SF36 subsets are Physical Role (rho =0.566 p<0.0001) and Bodily Pain (rho=0.444 p=0.0020). BDI correlates with HAQ-DI (rho=-0.655 p<0.0001). No statistically significant correlation was found between SF36, HAQ-DI and spirometrical values nor PFRA. Conclusions: The SSc patients enrolled have an impaired quality of life as widely demonstrated in literature. Quality of life reduction and functional ability decrease are only related to respiratory subjective impairment (assessed by BDI). Actually no correlation with objective lung damage (assessed by spirometry and PFRA) was detected.

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Published

14-09-2015

Issue

Section

ORIGINAL ARTICLES

How to Cite

1.
Quality of life and functional disability in patients with interstitial lung disease related to Systemic Sclerosis. Acta Biomed [Internet]. 2015 Sep. 14 [cited 2024 Jun. 16];86(2):142-8. Available from: https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/3997

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