Chronic pain treatment and scrambler therapy: a multicenter retrospective analysis

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Christian Compagnone
Fernanda Tagliaferri
Francesco Amato
Giovanna Ballerini
Filippo Berlinghieri
Laura Bertini
Giorgio Bordin
Pietro Buonavolontà
Alga Cascioli
Francesca Ceccaroni
Angela Cautillo
Alma Ciaschi
Lucia Maria Dodaro
Guido Fanelli
Francesca Greco
Paola Lesignoli
Ornella Martini
Alfonso Papa
Domenico Quatrone
William Raffaeli
Mediati Rocco
Renato Velluci


Scrambler therapy, chronic pain, post herpetic neuralgia, low back pain, polyneuropathy, peripheral neuropathy, persistent pain


Background and aim: Scrambler Therapy is a novel neuromodulation that works by electrocutaneous stimulation in a non-invasive manner through C fibers surface receptors. It substitutes pain information with synthetic “non pain” information. The primary aim of this study was to analyze the efficacy and safety of Scrambler Therapy after ten sessions related to different usage conditions and different learning curves that occur in a multi-center study. Methods: 201 patients have been treated with Scrambler Therapy. All the patients were suffering from chronic pain with a mean pain NRS of 7.41 (SD 2.06) before treatment. Main causes of chronic pain: post herpetic neuralgia 18.40 %, chronic low back pain (LBP) 37.31%, polyneuropathy 10.94%, and peripheral neuropathy 14.42 %. The remaining 18.93 % included chronic pain due to other causes. Results: The difference between pre-treatment NRS 7.41 (SD 2.06) and post-treatment 1.60 (SD 2.22) was statistically significant (P< 0.0001). The mean number of sessions per patient was 10, but 39 had complete absence of pain sooner and used fewer sessions. Only 7 patients stopped treatment due to lack of results, and 2 for personal reasons not ascribable to the treatment. Stimulation pain score of 0 during treatment, and not just pain reduction, predicts long term effectiveness, so this must be pursued by optimizing electrode positioning and correct fine-tuning of stimulation intensity. Conclusion: Scrambler Therapy is an efficient and safe alternative for several different types of refractory chronic neuropathic pain, with a very rare possibility of adverse events.


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