LISA: Surfactant administration in spontaneous breathing. Which evidence from the literature?

LISA: Surfactant administration in spontaneous breathing. Which evidence from the literature?

Authors

  • G. Lista NICU «V. Buzzi» Ospedale dei Bambini, ICP, Milan, Italy
  • A. La Verde NICU «V. Buzzi» Ospedale dei Bambini, ICP, Milan, Italy
  • F. Castoldi NICU «V. Buzzi» Ospedale dei Bambini, ICP, Milan, Italy

Keywords:

surfactant, spontaneous breathing, preterm infants, RDS

Abstract

Recent human and animal studies demonstrated that surfactant can be delivered intratracheally without traditional intubation and bagging, but using a fine catheter inserted into the trachea of spontaneously breathing preterm infants on CPAP. This strategy, known as LISA (less invasive surfactant administration) or MIST (minimal invasive surfactant therapy), seems to reduce failure of non-invasive respiratory approach. Avoiding mechanical ventilation and manual inflation it is possible to reduce lung injury due to baro-volutrauma. Moreover leaving the infants supported by N-CPAP during the maneuver, it is possible to reduce the risk of lung derecruitment. Further studies are needed to confirm the promising effects due to this strategy to deliver surfactant.

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Published

29-06-2015

How to Cite

1.
LISA: Surfactant administration in spontaneous breathing. Which evidence from the literature?. Acta Biomed [Internet]. 2015 Jun. 29 [cited 2024 May 19];86(1S):24-6. Available from: https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/4540