Phenotypic expression of Hashimoto’s thyroiditis is absolutely atypical in girls with Turner syndrome

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Giuseppina Salzano
Mariarosa Calafiore
Cristina Mignosa
Stefano Passanisi
Jessica Trombatore
Giuseppina Zirilli


autoimmune thyroid disorders, chromosomopathies, epidemiological peculiarities, thyroid function presenting pattern, thyroid function evolution pattern


Background: It is unknown whether phenotypic expression of Hashimoto’s thyroiditis (HT) might be conditioned by the association with Turner syndrome (TS). Objectives: To focus on the most recent pediatric studies concerning epidemiology and biochemical course of HT in TS girls. Design: The epidemiological peculiarities of TS-related HT in pediatric age were compared with those usually observed in non-TS girls with HT and results are summarized in Tables 1 and 2. Conclusions: 1) phenotypical expression of HT in TS girls is significantly different from that observed in girls without TS; 2) such differences concern the epidemiological picture, the biochemical presentation modes and also the natural history from HT diagnosis onwards; 3) these peculiarities of TS-related HT are not necessarily linked with a specific karyotype. 



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