The impact of different rheumatic diseases on health-related quality of life: a comparison with a selected sample of healthy individuals using SF-36 questionnaire, EQ-5D and SF-6D utility values

The impact of different rheumatic diseases on health-related quality of life: a comparison with a selected sample of healthy individuals using SF-36 questionnaire, EQ-5D and SF-6D utility values

Authors

  • Fausto Salaffi Rheumatology Department, Università Politecnica delle Marche, Jesi (Ancona), Italy
  • Marco Di Carlo Radiology Department, Università Politecnica delle Marche, Ancona, Italy
  • Marina Carotti DII Department of Information Engineering, Università Politecnica delle Marche, Ancona, Italy
  • Sonia Farah II Department of Information Engineering, Università Politecnica delle Marche, Ancona, Italy
  • Alessandro Ciapetti Rheumatology Department, Betsi Cadwaladr University Health Board, Glan Clwyd Hospital, Bodelwyddan, Denbighshire, Wales
  • Marwin Gutierrez Division of Musculoskeletal and Rheumatic Diseases, National Rehabilitation Institute, Mexico City, Mexico

Keywords:

Health-related quality of life, rheumatic diseases, SF-36, EQ-5D, SF-6D, patient-reported outcomes

Abstract

Background: Given the high prevalence of rheumatic diseases, there is a need to determine which conditions have the greatest impact on health-related quality of life (HRQoL). The main aim of this study was to explore the HRQoL scores among 14 different rheumatic diseases and to compare them with the results of a selecting sample of healthy controls. Methods: 2633 patients of an ongoing cohort have been enrolled. Rheumatic diseases were classified into five diagnostic groups: inflammatory rheumatic diseases, connective tissue disorders, symptomatic peripheral osteoarthritis, soft tissue disorders, and osteoporosis. For comparison were used 649 healthy controls. The HRQoL was evaluated with the Medical Outcomes Study Short-Form 36 Health Survey (SF-36), the EuroQol five Dimensions (EQ-5D) questionnaire, and the Short-Form six Dimensions (SF-6D) questionnaire. Results: The five major rheumatic disease groups, compared to healthy people, significantly impaired all eight health concepts of the SF-36 (p <0.0001). Similar results were found for EQ-5D and SF-6D. The patients with inflammatory rheumatic diseases have poorer self-reported health status than those without arthritis in all domains of living, but particularly with respect to scales measuring aspects of physical functioning or mobility, role limitation due to physical health problems and usual activities, and bodily pain. Rheumatoid arthritis had the largest negative impact on HRQoL, followed by fibromyalgia, vertebral fractures due to osteoporosis, hip osteoarthritis, and systemic sclerosis. Conclusions: Our results indicate that rheumatic diseases have a clearly detrimental effect on the HRQoL, and physical domain is more impaired than mental and social ones.

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Published

15-01-2019

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Section

ORIGINAL ARTICLES

How to Cite

1.
The impact of different rheumatic diseases on health-related quality of life: a comparison with a selected sample of healthy individuals using SF-36 questionnaire, EQ-5D and SF-6D utility values. Acta Biomed [Internet]. 2019 Jan. 15 [cited 2024 Jun. 23];89(4):541-57. Available from: https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/7298