Nutrition and lipidomic profile in colorectal cancers

Nutrition and lipidomic profile in colorectal cancers

Authors

  • Maria Notarnicola National Institute of Gastroenterology “S. De Bellis” Research Hospital, Castellana Grotte, Italy
  • Maria Gabriella Caruso National Institute of Gastroenterology “S. De Bellis” Research Hospital, Castellana Grotte, Italy
  • Valeria Tutino National Institute of Gastroenterology “S. De Bellis” Research Hospital, Castellana Grotte, Italy
  • Valentina De Nunzio National Institute of Gastroenterology “S. De Bellis” Research Hospital, Castellana Grotte, Italy
  • Isabella Gigante National Institute of Gastroenterology “S. De Bellis” Research Hospital, Castellana Grotte, Italy
  • Giampiero De Leonardis National Institute of Gastroenterology “S. De Bellis” Research Hospital, Castellana Grotte, Italy
  • Nicola Veronese National Institute of Gastroenterology “S. De Bellis” Research Hospital, Castellana Grotte, Italy
  • Ornella Rotolo National Institute of Gastroenterology “S. De Bellis” Research Hospital, Castellana Grotte, Italy
  • Rosa Reddavide National Institute of Gastroenterology “S. De Bellis” Research Hospital, Castellana Grotte, Italy
  • Elisa Stasi National Institute of Gastroenterology “S. De Bellis” Research Hospital, Castellana Grotte, Italy
  • Chiara Miraglia Department of Medicine and Surgery, University of Parma, Parma, Italy
  • Antonio Nouvenne Department of Medicine and Surgery, University of Parma, Parma, Italy
  • Tiziana Meschi Department of Medicine and Surgery, University of Parma, Parma, Italy
  • Gian Luigi de' Angelis Department of Medicine and Surgery, University of Parma, Parma, Italy
  • Francesco Di Mario Department of Medicine and Surgery, University of Parma, Parma, Italy
  • Gioacchino Leandro National Institute of Gastroenterology “S. De Bellis” Research Hospital, Castellana Grotte, Italy

Keywords:

nutrition, colorectal cancer, lipidomic analysis, fatty acids, lipoproteins

Abstract

Background: Adherence to a healthy diet has been reported to be essential for the primary prevention of colorectal cancer, through a reduction of tissue inflammation, a low concentration of circulating lipoproteins and lower levels of serum cholesterol. Since an altered expression of the fatty acids pattern has been demonstrated to be a crucial event in colorectal carcinogenesis, lipidomic analysis is considered able to identify early diagnostic and prognostic biomarkers of complex diseases such as colorectal cancer. Methods: cell membrane fatty acid profile and serum lipoproteins pattern were evaluated by gas chromatography and electrophoresis method respectively. Results: There is a close association between diet and lipidomic profile in colorectal cancer, both in pre-clinical and clinical studies. A modified serum lipoproteins pattern has been demonstrated to be predominant in intestinal tumors. Conclusions: The study of fatty acids profile in cell membrane and the evaluation of serum lipoproteins subfractions could be useful to have an integrate vision on the interactions between lipids and the pathogenesis of colorectal cancer and to understand the mechanisms of action and the consequences of these interactions on human health status.

Downloads

Published

17-12-2018

How to Cite

1.
Notarnicola M, Caruso MG, Tutino V, De Nunzio V, Gigante I, De Leonardis G, et al. Nutrition and lipidomic profile in colorectal cancers. Acta Biomed [Internet]. 2018 Dec. 17 [cited 2024 Jul. 19];89(9-S):87-96. Available from: https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/7955