Nutrition and lipidomic profile in colorectal cancers

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Maria Notarnicola
Maria Gabriella Caruso
Valeria Tutino
Valentina De Nunzio
Isabella Gigante
Giampiero De Leonardis
Nicola Veronese
Ornella Rotolo
Rosa Reddavide
Elisa Stasi
Chiara Miraglia
Antonio Nouvenne
Tiziana Meschi
Gian Luigi de' Angelis
Francesco Di Mario
Gioacchino Leandro


nutrition, colorectal cancer, lipidomic analysis, fatty acids, lipoproteins


Background: Adherence to a healthy diet has been reported to be essential for the primary prevention of colorectal cancer, through a reduction of tissue inflammation, a low concentration of circulating lipoproteins and lower levels of serum cholesterol. Since an altered expression of the fatty acids pattern has been demonstrated to be a crucial event in colorectal carcinogenesis, lipidomic analysis is considered able to identify early diagnostic and prognostic biomarkers of complex diseases such as colorectal cancer. Methods: cell membrane fatty acid profile and serum lipoproteins pattern were evaluated by gas chromatography and electrophoresis method respectively. Results: There is a close association between diet and lipidomic profile in colorectal cancer, both in pre-clinical and clinical studies. A modified serum lipoproteins pattern has been demonstrated to be predominant in intestinal tumors. Conclusions: The study of fatty acids profile in cell membrane and the evaluation of serum lipoproteins subfractions could be useful to have an integrate vision on the interactions between lipids and the pathogenesis of colorectal cancer and to understand the mechanisms of action and the consequences of these interactions on human health status.


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