Diagnosis of GERD in typical and atypical manifestations

Diagnosis of GERD in typical and atypical manifestations

Authors

  • Silvia Cesario Department of Medicine and Surgery, University of Parma, Parma, Italy
  • Serena Scida Department of Medicine and Surgery, University of Parma, Parma, Italy
  • Chiara Miraglia Department of Medicine and Surgery, University of Parma, Parma, Italy
  • Alberto Barchi Department of Medicine and Surgery, University of Parma, Parma, Italy
  • Antonio Nouvenne Department of Medicine and Surgery, University of Parma, Parma, Italy
  • Gioacchino Leandro National Institute of Gastroenterology “S. De Bellis” Research Hospital, Castellana Grotte, Italy
  • Tiziana Meschi Department of Medicine and Surgery, University of Parma, Parma, Italy
  • Gian Luigi de' Angelis Department of Medicine and Surgery, University of Parma, Parma, Italy
  • Francesco Di Mario Department of Medicine and Surgery, University of Parma, Parma, Italy

Keywords:

GERD, diagnosis, typical manifestations, atypical manifestations, pH impedance, gastrin 17

Abstract

The manifestations of gastroesophageal reflux disease (GERD) have been recently classified into either esophageal or extra-esophageal syndromes. Clinical history, questionnaire data and response to antisecretory therapy are insufficient to make a conclusive diagnosis of GERD. Endoscopy had a low sensitivity. Recently, the availability of multichannel intraluminal impedance and pH-monitoring (MII-pH) has modified the diagnostic approach towards atypical manifestations of GERD. There is a rising consensus that this technique should be considered as the gold standard for GERD diagnosis. Gastrin 17 (G-17) has been proposed as a non-invasive marker of GERD, due to the negative feedback between acid and the hormone. G17 levels seem able to identify patients with acid and non-acid reflux.

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Published

17-12-2018

How to Cite

1.
Diagnosis of GERD in typical and atypical manifestations. Acta Biomed [Internet]. 2018 Dec. 17 [cited 2024 Jun. 23];89(8-S):33-9. Available from: https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/7963