Radiation-induced brain cavernomas in elderly: review of the literature and a rare case report

Radiation-induced brain cavernomas in elderly: review of the literature and a rare case report

Authors

  • Giuseppe Mariniello Department of Neurosciences, Reproductive Sciences and Odontostomatology, Neurosurgical Clinic, University of Naples Federico II, Naples, Italy
  • Maria De Liso Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy
  • Camilla Russo Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy
  • Walter Del Vecchio Istitute of Biostructure and Bioimages IBB-CNR, Naples Italy
  • Oreste De Divitiis Department of Neurosciences, Reproductive Sciences and Odontostomatology, Neurosurgical Clinic, University of Naples Federico II, Naples, Italy
  • Federico Bruno Department of Biotechnology and Applied Clinical Sciences, University of L’Aquila, L’Aquila, Italy
  • Nicola Maggialetti Department of Medicine and Health Sciences "V. Tiberio", University of Molise, Campobasso, Italy
  • Francesco Arrigoni Department of Biotechnology and Applied Clinical Sciences, University of L’Aquila, L’Aquila, Italy
  • Luca Brunese Department of Medicine and Health Sciences "V. Tiberio", University of Molise, Campobasso, Italy
  • Ferdinando Caranci Department of Medicine and Health Sciences "V. Tiberio", University of Molise, Campobasso, Italy

Keywords:

Glioblastoma, Cavernous angioma, Radiotherapy

Abstract

Radiation-induced brain cavernomas have been mainly reported in children who underwent radiotherapy for medulloblastoma, leukemia, or low-grade glioma. Otherwise, the “de novo” appearance of a cavernoma in an elderly long-survivor patient after resection and radiotherapy of a glioblastoma is a rare event. We report the case of a 62-year-old female patient who underwent surgical resection of a right temporal glioblastoma, followed by radiation therapy of the operative field and surrounding brain and concomitant adjuvant temozolomide. Four years after the operation, a follow-up Magnetic Resonance revealed a good tumor control and a small round lesion at the superior surface of the right cerebellar hemisphere, close to the margins of the previous irradiation field. The radiological items were consistent with a cavernous angioma. Because of the small size of the malformation and the absence of related symptoms, no treatment was performed. The patient died for tumor progression 86 months after the initial operation, with unchanged cerebellar cavernoma. The occurrence of a cavernous angioma in an elderly patient after radiotherapy for brain glioblastoma is an exceptional event; the distribution of radiotherapy-induced cavernous malformations reported in current literature is presented and the mechanism of their formation is discussed.

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Published

24-04-2019

How to Cite

1.
Radiation-induced brain cavernomas in elderly: review of the literature and a rare case report. Acta Biomed [Internet]. 2019 Apr. 24 [cited 2024 Jun. 12];90(5-S):77-83. Available from: https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/8328

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