Acute abdominal pain in an adolescent girl  with an ovarian yolk sac tumor : A yolk sac tumor in an adolescent girl

Ettore Stefanelli; Valentina Talarico; Maria Scavone; Elena Carboni; Giuseppe Stranieri; Maria Concetta Galati; Domenico Salerno; Giuseppe Raiola

doi:10.23750/abm.v90i4.9017

Acute abdominal pain in an adolescent girl with an ovarian yolk sac tumor

A yolk sac tumor in an adolescent girl

Authors

Ettore Stefanelli Department of Pediatrics, Magna Graecia University of Catanzaro, Catanzaro, Italy
Valentina Talarico Department of Pediatrics, “Pugliese-Ciaccio” Hospital, Catanzaro, Italy
Maria Scavone Department of Pediatrics, Magna Graecia University of Catanzaro, Catanzaro, Italy
Elena Carboni Department of Pediatrics, Magna Graecia University of Catanzaro, Catanzaro, Italy
Giuseppe Stranieri Department of Pediatric Surgery, “Pugliese-Ciaccio” Hospital, Catanzaro, Italy
Maria Concetta Galati Department of Pediatric Oncohematology, “Pugliese-Ciaccio” Hospital, Catanzaro, Italy
Domenico Salerno Department of Pediatric Surgery, “Pugliese-Ciaccio” Hospital, Catanzaro, Italy
Giuseppe Raiola Department of Pediatrics, “Pugliese-Ciaccio” Hospital, Catanzaro, Italy

DOI: https://doi.org/10.23750/abm.v90i4.9017

Keywords:

yolk sac tumor, germ cell tumor, ovarian torsion, ovarian tumor, alpha-fetoprotein

Abstract

Yolk sac tumor (YST) is a rare tumor that usually occurs in the first two decades of life. It is considered the second most common malignant germ cell tumor of the ovary, characterized by a rapid growth and a bad prognosis due to the frequent metastasis. We report the case of a 12-year-old girl who came to our observation for an acute abdominal pain. Clinical examination evidenced a vague mass in the suprapubic region and a lower abdomen tenderness, the US imaging revealed a complex lesion of the left ovary (19 x 13 cm) and the alpha-fetoprotein (AFP) resulted high (5858 ng/mL). Computed tomography (CT) revealed a large pelvic mass. The treatment consisted of debulking surgery of yolk sac tumor followed by 4 cycles of BEP protocol (Bleomycin, Etoposide, Cisplatin). After 3 years of follow-up there was no evidence of disease recurrence. (www.actabiomedica.it)

References

1. Fujita M, Inoue M, Tanizawa O, Minagawa J, Yamada T, Tani T. Retrospective review of 41 patients with endodermal sinus tumor of the ovary. Int J Gynecol Cancer 1993; 3:329-335.
2. Caserta D, Ralli E, Bordi G, Moscarini M. An unusual clinical presentation of a pure yolk sac tumor of the ovary: case report. Eur J Gynaec Oncol 2013;34:577-579.
3. Mitchell PL, Al-Nasiri N, A'Hern R et al. Treatment of non-dysgerminomatous ovarian germ cell tumors: an analysis of 69 cases. Cancer 1999; 85:2232-2244.
4. Nawa A, Obata N, Kikkawa F et al. Prognostic factors of patients with yolk sac tumors of the ovary. Am J Obstet Gynecol 2001; 184:1182-1188.
5. von Allmen D. Malignant lesions of the ovary in childhood. Semin Pediatr Surg 2005;14:100–105.
6. Loh AH, Gee KW, Chua JH. Diagnostic accuracy of preoperative alpha-fetoprotein as an ovarian tumor marker in children and adolescents: not as good as we thought?. Pediatr Surg Int 2013; 29:709–713.
7. Eddaoualline H, Sami H, Rais H, Belbaraka R, El Omrani A, Khouchani M. Ovarian Yolk sac tumor: a case report and literature review. Clin Case Rep Int 2018; 2:1057.
8. Dallenbach P, BonnefoiH, Pelte MF, Vlastos G. Yolk sac tumors of the ovary: an update. Eur J Surg Oncol 2006; 32:1063-1075.
9. Fathalla AE, Shokralla HA. Yolk Sac Tumor of the Ovary in 18 Egyptian Cases: Does It Really Differ? J Cancer Ther 2016; 7:247-253.
10. Mckenney J, Heerema-McKenney A, Rouse RV. Extragonadal germ cell tumors: a review with emphasis on pathologic features, clinical prognostic variables, and differential diagnostic considerations. Adv Anat Pathol 2007; 14:69-92.
11. Jones RG, Akande MY, Younes HK, Jagarpu J, Mba N, Savell VH, Almond SP. Yolk sac tumor of the ovary in a young girl with tuberous sclerosis: A case report and review of the literature. Gynecol Oncol Rep 2014;10:9-12.
12. Tewari K, Cappuccini F, Disaia PJ, Berman ML, Manetta A, Kohler MF. Malignant germ cell tumors of the ovary. Obstet Gynecol 2000;95:128-133.
13. van den Akker M, Vervloessem D, Huybrechs A, Declercq S, van der Werff Ten Bosch J. Yolk sac tumor in the abdominal wall of an 18-month-old girl: a case report. J Med Case Rep 2017;11:47.
14. Christopher SC. Prepubertal Testicular and Paratesticular Tumors: Medscape Reference. New York, NY:WebMD LLC, 2011.
15. Khan IU, Jose J, Fawazy T, HadiWA, Sharma PK. Testicular yolk sac tumor in an eight-month old child: a case report. Gulf Med J 2012; 1:37–40.
16. Sell A, Sogaard H, Norgaard-Pedersen B. Serum alpha-fetoprotein as a marker for the effect of post-operative radiation therapy and/or chemotherapy in eight cases of ovarian endodermal sinus tumour. Int J Cancer 1976;18:574–580.
17. Guida M, Pignata S, Palumbo AR et al. Laparoscopic treatment of a yolk sac tumour: case report and literature review. Translational Med 2013;7:1-5.
18. Moniaga NC, Randall LM. Malignant mixed ovarian germ cell tumour with embryonal component. J Pediatr Adolesc Gynecol 2011;24:e1-e3.
19. Kawai M, Kano T, Furuhashi Y et al. Prognostic factors in yolk sac tumors of the ovary. A clinicopathologic analysis of 29 cases. Cancer 1991; 67:184–192.