The impact of rhinosinusitis in clinical practice: an Italian Survey

Main Article Content

Desiderio Passali
Valerio Damiani
Giulio Cesare Passali
Pasquale Cassano
Marco Piemonte
Giorgio Ciprandi


Italy, Survey, rhinosinusitis, general population, questionnaire, on the road


Rhinosinusitis is a common disease that is classified in acute (ARS) and chronic (CRS). The current Survey was conducted on a sample of about 5,000 adult subjects in 5 Italian cities. A questionnaire, containing 15 questions, was administered on the road. RS affects about 20% of the general population. The most common diagnostic test was the skull x-ray. Antibiotics were the most frequently prescribed therapy. In conclusion, the current Survey demonstrated that RS is a common disorder in Italy, the diagnostic work-up is still incorrect, and the therapeutic approach does not adhere to the guidelines. Therefore, there is a need to implement adequate information on this topic in Italy.


Download data is not yet available.
Abstract 255 | PDF Downloads 58


[1] R. Tan, S. Spector, Pediatric sinusitis. Curr. Allergy Asthma Rep 2007;7:21–426
[2] A. Magit, Pediatric rhinosinusitis. Otolaryngol Clin 2014;47:733–746
[3] E.R. Wald, K.E. Applegate, C. Bordley, et al. American Academy of Pediatrics. Clinical practice guidelines for the diagnosis and management of acute bacterial sinusitis in children aged 1 to 18 years. Pediatrics 2013;132:e262–e280
[4] C. Cyr, R. Racette, C.P. Leduc, C. Blais, Do symptoms and initial clinical probability predict the radiological diagnosis of acute sinusitis in children? Paediatr Child Health 2001;6:536–539
[5] D. Ueda, Y. Yoto, The ten-day mark as a practical diagnostic approach for acute paranasal sinusitis in children. Pediatr Infect Dis J 1996;15:576–579
[6] N. Bhattacharyya, D.T. Jones, M. Hill, N.L. Shapiro, The diagnostic accuracy of computed tomography in pediatric chronic rhinosinusitis. Arch Otolaryngol Head Neck Surg 2004;130:1029–1032
[7] H.H. Ramadan, Pediatric sinusitis: an update. J Otolaryngol 2005;34:S14–S17
[8] J.S. Glickstein, R.K. Chandra, J.W. Thompson, Intracranial complications of pediatric sinusitis. Otolaryngol Head Neck Surg 2006;134:733–736
[9] A.T. Peters, S. Spector, J. Hsu, et al. Joint task force on practice parameters, representing the American Academy of allergy, asthma and immunology, the American college of allergy, asthma and immunology, and the joint council of allergy, asthma and immunology. Diagnosis and management of rhinosinusitis: a practice parameter update. Ann Allergy Asthma Immunol 2014;113:347–385
[10] R.G. Slavin, S.L. Spector, I.L. Bernstein, et al. The diagnosis and management of sinusitis: a practice parameter update. J Allergy Clin Immunol 2005;116:S13–S47
[11] W.J. Fokkens, V.J. Lund, J. Mullol, et al. EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists. Rhinology 2012;50:1–12
[12] R.G. Slavin, Asthma and sinusitis. J Allergy Clin Immunol 1992;90:534–537
[13] G.L. Marseglia, S. Caimmi, A. Marseglia, et al. Rhinosinusitis and asthma. Int J Immunopathol Pharmacol 2010;23:29–31
[14] O. Matsuno, E. Ono, R. Takenaka, et al. Asthma and sinusitis: association and implication. Int Arch Allergy Immunol 2008;147:52–58
[15] S.E. Crater, E.J. Peters, C.D. Phillips, T.A. Platts-Mills. Prospective analysis of CT of the sinuses in acute asthma. Am J Roentgenol 1999;173:127–131
[16] A. ten Brinke, P.J. Sterk, A.A. Masclee, et al. Risk factors of frequent exacerbations in difficult-to-treat asthma. Eur Respir J 2005;26:812–818
17 M. Bresciani, L. Paradis, A. Des Roches, et al. Rhinosinusitis in severe asthma J Allergy Clin Immunol 2001;107:73–80
[18] O.V. Rossi, T. Pirilä, J. Laitinen, E. Huhti, Sinus aspirates and radiographic abnormalities in severe attacks of asthma. Int Arch Allergy Immunol 1994;103:209–213
[19] G.L. Marseglia, S. Caimmi, A. Marseglia, et al. Occult sinusitis may be a key feature for non-controlled asthma in children. J Biol Regul Homeost Agents 2012;26:S125–S131
[20] C.G. Fuller 1, J.J. Schoettler, V. Gilsanz, M.D. Nelson Jr., J.A. Church, W. Richards. Sinusitis in status asthmaticus. Clin Pediatr 1994;33:712–719
[21] M.A. Tosca, C. Cosentino, E. Pallestrini, G. Caligo, M. Milanese, G. Ciprandi, Improvement of clinical and immunopathologic parameters in asthmatic children treated for concomitant chronic rhinosinusitis. Ann Allergy Asthma Immunol 2003;91:71–78
[22] P. Giavina-Bianchi, M.V. Aun, et al. United airway disease: current perspectives. J Asthma Allergy 2016;9:93–100
[23] Hastan D, Fokkens WJ, Bachert C, et al. Chronic rhinosinusitis in Europe–an underestimated disease. A GA2LEN study. Allergy. 2011;66(9):1216-1223.
[24] Hirsch AG, Stewart WF, Sundaresan AS, et al. Nasal and sinus symptoms and chronic rhinosinusitis in a population-based sample. Allergy. 2017;72(2):274-281
[25] Ostovar A, Fokkens WJ, Vahdat K, Raeisi A, Mallahzadeh A, Farrokhi S. Epidemiology of chronic rhinosinusitis in Bushehr, the southwestern region of Iran: a GA2LEN study. Rhinology. 2018;57(1):43-48
[26] Shi JB, Fu QL, Zhang H, et al. Epidemiology of chronic rhinosinusitis: results from a cross-sectional survey in seven Chinese cities. Allergy. 2015;70(5):533-539
[27] Fokkens WJ, Lund VJ, Mullol J et al. European Position Paper on Rhinosinusitis and Nasal Polyps 2012. Rhinol Suppl. 2012;23:1-298
[28] Dietz de Loos D, Lourijsen ES, Wildeman M, et al. Prevalence of chronic rhinosinusitis in the general population based on sinus radiology and symptomatology. J Allergy Clin Immunol. 2019;143(3):1207-1214
[29] Tomassen P, Newson RB, Hoffmans R, et al. Reliability of EP3OS symptom criteria and nasal endoscopy in the assessment of chronic rhinosinusitis–a GA(2) LEN study. Allergy. 2011;66(4):556-561
[30] Khan A, Vandeplas G, Huynh T, et al. The global allergy and asthma European network (GALEN rhinosinusitis cohort: a large European cross-sectional study of chronic rhinosinusitis patients with and without nasal polyps. Rhinology. 2019;57(1):32-42
[31] Kowalski ML, Agache I, Bavbek S et al. Diagnosis and management of NSAID-exacerbated respiratory disease (N-ERD)-a EAACI position paper. Allergy. 2019;74(1):28-39
[32] Philpott CM, Erskine S, Hopkins C, et al. Prevalence of asthma, aspirin sensitivity and allergy in chronic rhinosinusitis: data from the UK National Chronic Rhinosinusitis Epidemiology Study. Respir Res. 2018;19(1):129
[33] Wu D, Bleier BS, Li L, et al. Clinical phenotypes of nasal polyps and comorbid asthma based on cluster analysis of disease history. J Allergy Clin Immunol Pract. 2018;6(4):1297-305
[34] Liao B, Liu J-X, Li Z-Y, et al. Multidimensional endotypes of chronic rhinosinusitis and their association with treatment outcomes. Allergy 2018;73(7):1459-1469
[35] Tomassen P, Vandeplas G, Van Zele T, et al. Inflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers. J Allergy Clin Immunol. 2016;137(5):1449-1456.e4
[36] Langdon C, Mullol J. Nasal polyps in patients with asthma: prevalence, impact, and management challenges. J Asthma Allergy. 2016;9:45-53
[37] Lin DC, Chandra RK, Tan BK, et al. Association between severity of asthma and degree of chronic rhinosinusitis. Am J Rhinol Allergy. 2011;25(4):205-208
[38] Shaw DE, Sousa AR, Fowler SJ, et al. Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort. Eur Respir J. 2015;46(5):1308-1321

Most read articles by the same author(s)

1 2 3 4 5 6 > >>