WHO International Health Regulations (IHR) vs COVID-19 Uncertainty

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Astrid Stuckelberger
Manuel Urbina




One of WHO primary function is to control and monitor internationally the spread of infectious diseases of the common killers. After SARS-COV, the International Health Regulations (IHR) was adopted in 2005 by all 194 member states to set up national preparedness for an efficient “early alert and response system”. COVID-19 is a novel virus with an unpredictable course and many uncertainties about its biological, clinical and epidemiological characteristics. COVID-19 is a game changer and calls for a revision of IHR as well as a more biological, clinical and community-cantered preparedness strategy.



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1. WHO, Basic Documents, 48th Edition, WHO, Geneva, 2014. https://apps.who.int/gb/bd/PDF/bd48/basic-documents-48th-edition-en.pdf
2. Markel, H. (2014). Worldly approaches to global health: 1851 to the present. Public Health, 128(2), 124–128.
3. Stern A, Markel H. International efforts to control infectious diseases, 1851 to the present. J Am Med Assoc, 2004;292(12):1474e9.
4. Gostin LO. International infectious disease law: revision of the World Health Organization’s international health regulations. J Am Med Assoc 2004;291(21):2623e7.
5. World Health Organization. Summary of probable SARS cases with onset of illness from 1 November 2002 to 31 July 2003 (based on data as of the 31 December 2003) http://www.who.int/csr/sars/country/table2004_04_21/en
7. WHO, Checklist and Indicators for monitoring progress in the development of IHR capacities in States Parties, WHO Geneva, WHO/HSE/IHR/2010.1.Rev.1, February 2011
8. Stuckelberger Astrid, Synthesis of the instructional design and education material developed by the University of Geneva for the WHO IHR implementation training and i-Course from 2009 to 2012, Internal document, University of Geneva: Switzerland.
9. Kandel, Nirmal et al, Health security capacities in the context of COVID-19 outbreak: an analysis of International Health Regulations annual report data from 182 countries, The Lancet, 28 March 2020, Volume 395 (10229): 1047 - 1053
10. Gostin LO, Katz R. The International Health Regulations: The Governing Framework for Global Health Security. Milbank Q. 2016;94(2):264–313. doi:10.1111/1468-0009.12186
11. Kahn, Jeffrey S. MD, PhD*; McIntosh, Kenneth MD† History and Recent Advances in Coronavirus Discovery, The Pediatric Infectious Disease Journal: November 2005, Volume 24 - Issue 11 - p S223-S227
12. Haagmans BL, Albert DME, Osterhaus, in Vaccines for Biodefense and Emerging and Neglected Diseases, 2009, Chapter 36: 671-683.
13. Poutanen SM, Human Coronaviruses, Editor(s): Sarah S. Long, Charles G. Prober, Marc Fischer, In Principles and Practice of Pediatric Infectious Diseases (Fifth Edition), Elsevier, 2018, Chapter 222 (III, B): 1148-1152.
14. Katz R, Dowell SF, Revising the International Health Regulations: call for a 2017 review conference, The Lancet, Vol 3: e352-e353.
15. Cucinotta D, Vanelli M, WHO Declares COVID-19 a Pandemic, Acta Biomedica, 2020, Vol. 91(1): 157-160.
16. Eisenberg J, R0: How Scientists Quantify the Intensity of an Outbreak Like Coronavirus and Its Pandemic Potential, The Conversation, Michigan University School of Public Health, 27 March 2020. https://sph.umich.edu/pursuit/2020posts/how-scientists-quantify-outbreaks.html
17. Zhao et al., Relationship between the ABO Blood Group and the COVID-19 Susceptibility, medRxiv, 11 March 2020, 20031096. https://www.medrxiv.org/content/10.1101/2020.03.11.20031096v2
18 Gandhi M, P.H., Yokoe D S, Havlir DV, Asymptomatic Transmission, the Achilles’ Heel of Current Strategies to Control Covid-19, New England Journal of Medicine, Editorial, published online on 24 April 2020. https://www.nejm.org/doi/full/10.1056/NEJMe2009758
19. United Nations, Protecting Humanity from Future Health Crises, Report of the High-level Panel on the Global Response to Health Crises, Global Health Crisis Task Force, 7th Session of the UN General Assembly, A/70/723, Item 125: Global health and foreign policy, 2016. https://www.un.org/en/global-health-crises-task-force/