Small airways in children with allergic rhinoconjunctivitis: the potential role of a multicomponent nutraceutical

Main Article Content

Salvatore Leonardi
Giuseppe Parisi
Maria Papale
Anna Maria Zicari
Roberta Olcese
Amelia Licari
Gianluigi Marseglia
Giorgio Ciprandi

Keywords

allergic rhinitis, children, spirometry, asthma, MEF50, nutraceutical

Abstract

Allergic rhinitis and asthma are closely linked. A progression from rhinitis to overt asthma is common. FEF25-75 is a spirometry parameter that could reflect small airways patency and could reliably predict early bronchial involvement in allergic rhinitis patients. MEF50 very strongly correlates with FEF25-75. The aim of this study was to evaluate possible spirometry change in two groups of children suffering from AR over time. The first group took a course of a nutraceutical (Lertal®) before the observation (active group, AG); a second one was considered as control (control group, CG). The children were visited at baseline, at the end of the nutraceutical course, and after 1 year. FEV1, FVC, and MEF50 were the primary outcomes. After one year, children in AG had significantly higher MEF50 than CG children (p=0.009). In conclusion, the present study showed that a course with a multicomponent nutraceutical could prevent the MEF50 decline in children with allergic rhinoconjunctivitis.

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