Small airways in children with allergic rhinoconjunctivitis: the potential role of a multicomponent nutraceutical

Small airways in children with allergic rhinoconjunctivitis: the potential role of a multicomponent nutraceutical

Authors

  • Salvatore Leonardi Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy University
  • Giuseppe Parisi Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy University
  • Maria Papale Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy University
  • Anna Maria Zicari Pediatrics Department, Umberto I Hospital, Roma, Sapienza University, Roma, Italy
  • Roberta Olcese Allergy Center, Istituto Giannina Gaslini, Genoa, Italy
  • Amelia Licari Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
  • Gianluigi Marseglia Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
  • Giorgio Ciprandi Allergy Clinic, Villa Montallegro, Genoa, Italy

Keywords:

allergic rhinitis, children, spirometry, asthma, MEF50, nutraceutical

Abstract

Allergic rhinitis and asthma are closely linked. A progression from rhinitis to overt asthma is common. FEF25-75 is a spirometry parameter that could reflect small airways patency and could reliably predict early bronchial involvement in allergic rhinitis patients. MEF50 very strongly correlates with FEF25-75. The aim of this study was to evaluate possible spirometry change in two groups of children suffering from AR over time. The first group took a course of a nutraceutical (Lertal®) before the observation (active group, AG); a second one was considered as control (control group, CG). The children were visited at baseline, at the end of the nutraceutical course, and after 1 year. FEV1, FVC, and MEF50 were the primary outcomes. After one year, children in AG had significantly higher MEF50 than CG children (p=0.009). In conclusion, the present study showed that a course with a multicomponent nutraceutical could prevent the MEF50 decline in children with allergic rhinoconjunctivitis.

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11-05-2020

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1.
Leonardi S, Parisi G, Papale M, Zicari AM, Olcese R, Licari A, et al. Small airways in children with allergic rhinoconjunctivitis: the potential role of a multicomponent nutraceutical. Acta Biomed [Internet]. 2020 May 11 [cited 2024 Oct. 12];91(2):350-5. Available from: https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/9641