Transition of care in pediatric oncohematology: a systematic literature review

Transition of care in pediatric oncohematology: a systematic literature review


  • Veronica Strini a:1:{s:5:"en_US";s:17:"Hospital of Padua";}
  • Chiara Daicampi
  • Nicola Trevisan
  • Anna Marinetto
  • Angela Prendin
  • Elena Marinelli
  • Ilaria de Barbieri


oncology, sickle cell disease, pediatric, nurse, transition, review, models, organization care, cancer


Background: The transition of medical care from a pediatric to an adult environment is a psychological change, a new orientation that requires a self-redefinition of the individual, to understand that changes are taking place in his life. Up to 60 percent of pediatric patients who transition to adult services will experience one or more disease or treatment-related complication as they become adults. A nurse who knows how to recognize potential barriers at an early stage can play a pivotal role in the educational plan for the transition process. Materials and methods: A literature search was undertaken of PUBMED, CINAHL and The Cochrane Library, with specific inclusion and exclusion criteria, including articles published in the lasts ten years.This literature review has been performed according to the PRISMA statement. Results: Using the keywords in different combination 38 articles were found in The Cochrane Library, 5877 in PUBMED, 274 in CINAHL. 88 articles were selected after the abstract screening. 31 after removing the duplicates and reading the full text. Discussion: The main themes surrounding transition of care that emerged from the synthesis are the organization of care within common models of transition, innovative clinical approaches to transition, and the experience of patients and caregivers. The transition from pediatric to adult care of cancer or SCD survivors is an emerging topic in pediatric nursing. The organization of care is affected by the lack of clear and well-structured organizational models. Further research is needed to deepen the understanding of some aspects of the transition.


Bashore L, Bender J. Evaluation of the Utility of a Transition Workbook in Preparing Adolescent and Young Adult Cancer Survivors for Transition to Adult Services: A Pilot Study. J Pediatr Oncol Nurs 2016: 33(2): 111-8

Blum RW, Garell D, Hodgman CH, et al. Transition from child-centered to adult healthcare systems for adolescents with chronic conditions. A position paper of the society for adolescent medicine. J Adolesc Health 1993: 14: 570-576

Henderson TO, Friedman DL, Meadows AT. Childhood cancer survivors: transition to adult-focused risk-based care. Pediatrics 2010: 126(1): 129-36

Jin YT, Chen CM, Chien WC. Factors influencing transitional care from adolescents to young adults with cancer in Taiwan: A population-based study. BMC Pediatr 2016: 16: 122

Schwartz LA, Tuchman LK, Hobbie WL, Ginsberg JP. A social-ecological model of readiness for transition to adult-oriented care for adolescents and young adults with chronic health conditions. Child Care Health Dev 2011: 37(6): 883-95

Mulder RL, van der Pal HJH, Levitt GA, et al. Transition guidelines: An important step in the future care for childhood cancer survivors. A comprehensive definition as groundwork. Eur J Cancer 2016: 54: 64-68

Oeffinger KC, Mertens AC, Hudson MM, et al. Health care of young adult survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. Ann Fam Med 2004: 2(1): 61-70

Mouw MS, Wertman EA, Barrington C, Earp JA. Care Transitions in Childhood Cancer Survivorship: Providers' Perspectives. J Adolesc Young Adul 2017: 6(1): 111-119

McInally W, Cruickshank S. Transition from child to adult services for young people with cancer. Nurs Child Young People 2013: 25(1): 14-8

Bryant R, Porter JS, Sobota A, Association of Pediatric Hematology/Oncology Nurses, American Society of Pediatric Hematology Oncology. APHON/ASPHO Policy Statement for the Transition of Patients With Sickle Cell Disease From Pediatric to Adult Health Care. J Pediatr Oncol Nurs 2015: 32(6): 355-9

Bemrich-Stolz CJ, Halanych JH, Howard TH, Hilliard LM, Lebensburger JD. Exploring Adult Care Experiences and Barriers to Transition in Adult Patients with Sickle Cell Disease. Int J Hematol Ther 2015: 1(1)

Kenney LB, Melvin P, Fishman LN, et al. Transition and transfer of childhood cancer survivors to adult care: A national survey of pediatric oncologists. Pediatr Blood Cancer 2017: 64(2): 346-352

Sadak KT, Dinofia A, Reaman G. Patient-perceived facilitators in the transition of care for young adult survivors of childhood cancer. Pediatr Blood Cancer 2013: 60(8): 1365-8

Nandakumar BS, Fardell JE, Wakefield CE, et al. Attitudes and experiences of childhood cancer survivors transitioning from pediatric care to adult care. Support. Care Cancer 2018: 26(8): 2743-2750

Quillen J, Bradley H, Calamaro C. Identifying Barriers Among Childhood Cancer Survivors Transitioning to Adult Health Care. J Pediatr Oncol Nurs 2017: 34(1): 20-27

Moher D, Liberati A, Tetzlaff J, Altman DG, The PRISMA Group. Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. PLoS Med 2009: 3(3): 123-130.

Kanter J, Kruse-Jarres R. Management of sickle cell disease from childhood through adulthood. Blood Rev 2013: 27(6): 279-87

Freyer DR, Brugieres L. Adolescent and young adult oncology: transition of care. Pediatr. Blood Cancer 2008: 50(5 Suppl): 1116-9

Freyer DR. Transition of care for young adult survivors of childhood and adolescent cancer: rationale and approaches. J Clin Oncol 2010:28(32): 4810-8

Granek L, Nathan PC, Rosenberg-Yunger ZR, et al. Psychological factors impacting transition from paediatric to adult care by childhood cancer survivors. J Cancer Surviv 2012: 6(3): 260-9

Nathan PC, Hayes-Lattin B, Sisler JJ, Hudson MM. Critical issues in transition and survivorship for adolescents and young adults with cancers. Cancer 2011: 117(10 Suppl): 2335-41

Andemariam B, Owarish-Gross J, Grady J, Boruchov D, Thrall RS, Hagstrom JN. Identification of risk factors for an unsuccessful transition from pediatric to adult sickle cell disease care. Pediatr Blood Cancer 2014: 61(4): 697-701

Sobota A, Neufeld EJ, Sprinz P, Heeney MM. Transition from pediatric to adult care for sickle cell disease: results of a survey of pediatric providers. Am J Hematol 2011: 86(6): 512-5

Frederick NN, Bober SL, Berwick L, Tower M, Kenney LB. Preparing childhood cancer survivors for transition to adult care: The young adult perspective. Pediatr Blood Cancer 2017: 64(10)

Ganju RG, Nanda RH, Esiashvili N, Switchenko JM, Wasilewski-Masker K, Marchak JG. The Effect of Transition Clinics on Knowledge of Diagnosis and Perception of Risk in Young Adult Survivors of Childhood Cancer. J Pediatr Hematol Oncol 2016: 38(3): 197-201

Klassen AF, Rosenberg-Yunger ZR, D'Agostino NM, et al. The development of scales to measure childhood cancer survivors' readiness for transition to long-term follow-up care as adults. Health Expect 2015: 18(6): 1941-55

Sobota AE, Shah N, Mack JW. Development of quality indicators for transition from pediatric to adult care in sickle cell disease: A modified Delphi survey of adult providers. Pediatr Blood Cancer 2017: 64(6)

Sobota AE, Umeh E, Mack JW. Young Adult Perspectives on a Successful Transition from Pediatric to Adult Care in Sickle Cell Disease. J Hematol Res 2015: 2(1): 17-24

McPherson M, Thaniel L, Minniti CP. Transition of patients with sickle cell disease from pediatric to adult care: Assessing patient readiness. Pediatr Blood Cancer 2009: 52(7): 838-41

Schwartz LA, Brumley LD, Tuchman LK, et al. Stakeholder validation of a model of readiness for transition to adult care. JAMA Pediatr 2013: 167(10): 939-46

Svedberg P, Einberg EL, Wärnestål P, et al. Support from healthcare services during transition to adulthood - Experiences of young adult survivors of pediatric cancer. Eur J Oncol Nurs 2016: 21: 105-12

Fernandes SM, O’Sullivan-Oliveira J, Landzberg MJ, et al. Transitioning and Transfer of Adolescents and Young Adults with Pediatric Onset Chronic Disease: The Patient and Parent Perspective. J Pediatr Rehabil Med 2014: 7(1): 43–51.

Margolis R, Wiener L, Pao M, Malech HL, Holland SM, Driscoll P. Transition From Pediatric to Adult Care by Young Adults With Chronic Granulomatous Disease: The Patient's Viewpoint. J Adolesc Health 2017: 61(6): 716-721

Sadak KT, Neglia JP, Freyer DR, Harwood E. Identifying metrics of success for transitional care practices in childhood cancer survivorship: A qualitative study of survivorship providers. Pediatr Blood Cancer 2017: 64(11)

Szalda D, Pierce L, Hobbie W, et al. Engagement and experience with cancer-related follow-up care among young adult survivors of childhood cancer after transfer to adult care. J Cancer Surviv 2016: 10(2): 342-50

DiNofia A, Shafer K, Steacy K, Sadak KT. Parent-perceived Facilitators in the Transition of Care for Young Adult Survivors of Childhood Cancer. J Pediatr Hematol Oncol 2017: 39(7): e377-e380




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Transition of care in pediatric oncohematology: a systematic literature review . Acta Biomed [Internet]. 2020 Jun. 20 [cited 2024 Jun. 13];91(6-S):48-64. Available from: