Intranasal NGF in pediatric brain injury: the dawn of neurorepair?

Lorenzo Di Sarno; Valeria Pansini; Anya Caroselli; Antonio Gatto; Serena Ferretti; Antonio Chiaretti

doi:10.23750/abm.2026.19013

This is a preview and has not been published.

Intranasal NGF in pediatric brain injury: the dawn of neurorepair?

Authors

Lorenzo Di Sarno Department of Pediatrics, Fondazione Policlinico “A. Gemelli”, IRCCS, 00168, Rome, Italy https://orcid.org/0000-0002-4837-9297
Valeria Pansini Department of Pediatrics, Fondazione Policlinico “A. Gemelli”, IRCCS, 00168, Rome, Italy https://orcid.org/0000-0002-0589-8011
Anya Caroselli Department of Pediatrics, Fondazione Policlinico “A. Gemelli”, IRCCS, Università Cattolica del Sacro Cuore, 00168, Rome, Italy https://orcid.org/0009-0004-0254-1115
Antonio Gatto Department of Pediatrics, Fondazione Policlinico “A. Gemelli”, IRCCS, 00168, Rome, Italy https://orcid.org/0000-0002-8778-9328
Serena Ferretti Department of Pediatrics, Fondazione Policlinico “A. Gemelli”, IRCCS, 00168, Rome, Italy https://orcid.org/0000-0001-6479-1540
Antonio Chiaretti Department of Pediatrics, Fondazione Policlinico “A. Gemelli”, IRCCS, Università Cattolica del Sacro Cuore, 00168, Rome, Italy https://orcid.org/0000-0002-9971-1640

Keywords:

NGF, brain injury, pediatric

References

Di Sarno L, Curatola A, Cammisa I, et al. Non-pharmacologic approaches to neurological stimulation in patients with severe brain injuries: a systematic review. Eur Rev Med Pharmacol Sci. 2022;26(18):6856-6870. doi: 10.26355/eurrev_202209_29789.

Chiaretti A, Eftimiadi G, Buonsenso D, Rendeli C, Staccioli S, Conti G. Intranasal nerve growth factor administration improves neurological outcome after GBS meningitis. Childs Nerv Syst. 2020;36(9):2083-2088. doi: 10.1007/s00381-020-04590-x.

Di Sarno L, Ferretti S, Capossela L, et al. Neurofunctional and Clinical Effects of Intranasal Human Recombinant Nerve Growth Factor in Children with Acquired Brain Injury. Pharmaceuticals. 2026;19(4):590. doi: 10.3390/ph19040590.

Gatto A, Capossela L, Conti G, et al. Intranasal human-recombinant NGF administration improves outcome in children with post-traumatic unresponsive wakefulness syndrome. Biol Direct. 2023;18(1):61. doi: 10.1186/s13062-023-00418-1.

Di Sarno L, Capossela L, Ferretti S, et al. Intranasal Human-Recombinant Nerve Growth Factor Enhances Motor and Cognitive Function Recovery in a Child with Severe Traumatic Brain Injury. Pharmaceuticals. 2025;18(2):163. doi: 10.3390/ph18020163.

Capossela L, Graglia B, Ferretti S, et al. Intranasal human-recombinant nerve growth factor administration improves cognitive functions in a child with severe traumatic brain injury. Eur Rev Med Pharmacol Sci. 2024;28(18):4302-4312. doi: 10.26355/eurrev_202409_36790.

How to Cite

Di Sarno L, Pansini V, Caroselli A, Gatto A, Ferretti S, Chiaretti A. Intranasal NGF in pediatric brain injury: the dawn of neurorepair?. Acta Biomed. 97:19013. doi:10.23750/abm.2026.19013

Download Citation

Issue

Vol. 97 (2026): ONLINE FIRST - Acta Biomedica 2026; volume 97

Section

LETTERS TO THE EDITOR AND CORRESPONDENCE

DOI: https://doi.org/10.23750/abm.2026.19013

License

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Transfer of Copyright and Permission to Reproduce Parts of Published Papers.
Authors retain the copyright for their published work. No formal permission will be required to reproduce parts (tables or illustrations) of published papers, provided the source is quoted appropriately and reproduction has no commercial intent. Reproductions with commercial intent will require written permission and payment of royalties.

How to Cite

Di Sarno L, Pansini V, Caroselli A, Gatto A, Ferretti S, Chiaretti A. Intranasal NGF in pediatric brain injury: the dawn of neurorepair?. Acta Biomed. 97:19013. doi:10.23750/abm.2026.19013

Download Citation