Short-term feeding with high fructose diet impairs bone mineralization in growing rats

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Angelika Manterys
Agnieszka Filipiak-Florkiewicz
Adam Florkiewicz
Magdalena Franczyk-Zarow
Edyta Kus
Marek Sady
Renata B. Kostogrys


high fructose diet, bone mineralization, calcium homeostasis, rats


Aim: The objective of this study was to investigate effects of short-term, high fructose intake on mineralization and biomechanical strength of bones in growing rats. Methodology: Male Wistar rats (aged 8 weeks) were divided into two experimental groups. Animals were fed with AIN 93G diet or high fructose diet, containing 63 wt% of fructose, for four weeks. Bone calcium and phosphorus content were determined according to PN-EN 15505:2009 norm and AOAC 986.24-1988 method, respectively. The bones biomechanical strength was tested using texture analyzer. Results: Feeding rats with high fructose diet resulted in significant (p<0,05) decrease of calcium content in femur and tibia. Also phosphorus content was significantly (p<0,05) decreased in femoral bone from animals fed high fructose diet. The biomechanical strength of femur and tibia was slightly lower in high fructose group compared to control. Conclusion: Short-term high fructose intake impairs calcium and phosphorus bone deposition in growing animals.


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