A mixture of vegetable extracts (chamomile, passionflower, caraway, fennel) and enzymes (beta-galactosidase) for Irritable Bowel Syndrome (IBS): an observational study ("BIOVES") STUDIO "BIOVES"

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Giovanni Tomasello http://orcid.org/0000-0002-3071-822X
Vincenzo Davide Palumbo
Emanuele Sinagra
Margherita Mazzola
Agostino Accardo
Andrea Busalacchi
Antonio Ciulla
Benedetto Di Trapani
Paolo Pirrotta
Simone Tomasini
Bartolo De Luca
Simona Cusimano
Salvatore Sardo
Giuseppina Di Gaetano
Claudia Corallo
Gianluca Bonetti
Monica Pellerone
Giulia Tomasello
Provvidenza Damiani
Francesco Carini


irritable bowel syndrome, gastroenterology, alternative treatments


Aims: Irritable bowel syndrome (IBS) is a functional intestinal disorder. This syndrome may creates psychological disorders in patients who are affected and severely limits daily activities and lifestyle. Methods: We investigated the effect of the natural product consisting of chamomile, fennel, caraway, passionflower and melissa (Spasmicol®), on IBS patients. For the study, 187 patients with IBS, enrolled by primary care doctors, were treated with Spasmicol® (Aristeia Farmaceutici s.r.l.), two tablets/daily, for 30 days. At the end of the study, patients were re-evaluated to analyse the effects of therapy. Results: After 30 days, patients showed a marked reduction of symptoms (abdominal pain, abdominal distention, stool habit changes). Conclusions: Due to to the combination of chamomile, fennel, caraway, melissa, passionflower and beta-galactosidase, the product Spasmicol® turned out to be remarkedly effective in treating IBS symptoms.

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