Effects of walnut-enriched diet on blood lipids and glucose profiles in hyperlipidemic subjects: a randomized-controlled trial

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Gozde Okburan
Seyit Mehmet Mercanlıgil
Seray Kabaran
Sultan Ogmen


Walnut, Hyperlipidemia, Serum Cholesterol, Serum Glucose, Serum Insulin,  HOMA-IR


Background and Objectives: Walnuts have been shown to reduce serum lipids in hyperlipidemic individuals with a well-controlled feeding trials. Current study have been determined the effects of daily walnut consumption on serum lipids, fasting glucose and insulin levels in hyperlipidemic subjects. Subjects and Methods: In this, randomized controlled trial, mild to moderate hyperlipidemic subjects were randomly divided into 2 groups as walnut-enriched (n=20) and control (n=17) groups for 6 weeks. All subjects adhered to a medical nutrition therapy as low-fat and low-cholesterol diet. The walnut-enriched group was supplemented with 40 g/day of walnuts added to their diets. In order to follow nutritional and physical activity status of all subjects, they were visited every 15 days (in total 4 times). Anthropometric measurements of the subjects were taken and were monitored at each visit during the study. Blood samples were measured at the beginning and at the end of the study. Results: Our study showed that enriching a well controlled diet with walnuts (40g/day) improves the plasma lipid as well as serum glucose levels after the 6-week. Both groups showed a decrease in serum lipids with adaptation to the AHA (Americen Heart Association) diet, but statistically significant reductions (p<0.05) in serum glucose, insulin and HOMA-IR levels were found especially walnut-enriched group showed significant decrease in their total cholesterol and low-density lipoprotein cholesterol (LDL-C) by %5.3 (p= 0.02) and %8.8 (p= 0.0)respectively. Also LDL:HDL ratio and total cholesterol:HDL cholesterol ratio was significantly decreased in walnut-enriched group (p<0.05). Fasting glucose and fasting insulin levels decreased by %15.7 and %15.4 in walnut-enriched group, respectively. Walnut consumption did not show any significant changes in either high-density lipoprotein (HDL) cholesterol and triglyceride (TG) levels. Conclusions: This study indicated that, walnut-enriched diet improves serum glucose and serum lipids in hyperlipidemic subjetcs, suggesting a potential reduction in overall cardiac risk.


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