Factors influencing quality of life in cancer patients receiving haemodialysis

Main Article Content

Kadir Gokhan Atilgan https://orcid.org/0000-0001-9905-4305
Mehmet Deniz Ayli https://orcid.org/0000-0003-3145-1595
Tulay Eren https://orcid.org/0000-0002-0088-1149
Cengiz Karacin https://orcid.org/0000-0002-7310-9328
Hatice Sahin https://orcid.org/0000-0002-7146-4828
Tamer Selen https://orcid.org/0000-0003-2617-2372
Ebru Gok Oguz
Fatma Ayerden Ebinc https://orcid.org/0000-0002-7893-3498
Gulay Ulusal Okyay https://orcid.org/0000-0003-0770-1283

Keywords

cancer, hand grip strength, haemodialysis, inflammation, malnutrition, physical activity, quality of life

Abstract

Background: Life expectancy in cancer patients is shorter than in the general population. Therefore
quality of life is important. The quality of life and the affecting factors in cancer patients receiving haemodialysis
(HD) treatment are not clearly known. Objective: This study evaluated factors affecting quality of life in cancer
patients undergoing HD compared to patients without cancer undergoing HD. Methods: The study was conducted between May 2019 and September 2019. The dialysis unit of the authors’ hospital and ten private HD
centres participated in the present case control study. The study included 37 cancer patients undergoing HD
(Group CA) and age, sex matched 37 patients undergoing HD without cancer (Group C). Quality of life was
assessed with the health-related quality of life short form-36. Muscle mass and malnutrition were evaluated with the hand grip strength (HGS) test and malnutrition-inflammation score (MIS). Sleep disorder was assessed
using the Pittsburgh sleep quality index (PSQI). Results: In Group CA, HGS was significantly related to both
mental composite scores and mental health (p = 0.023, r = 0.374; p < 0.001, r = 0.519, respectively). In Group C,
a significant relationship was detected between HGS and both physical composite scores and general health (p
= 0.03, r = 0.356; p = 0.017, r = 0.397, respectively), between the PSQI and physical role functioning (p = 0.03, r
= -0.336) and between the MIS and HGS (p = 0.012, r = -0.408). Conclusion: Only HGS affected quality of life
in cancer patients undergoing receiving HD treatment.

Downloads

Download data is not yet available.
Abstract 50 | PDF Downloads 60

References

1. Humphreys BD, Soiffer RJ, Magee CC. Renal Failure Associated with Cancer and Its Treatment: An Update. J Am Soc Nephrol 2005, 16(1):151-161.
2. Kitchlu A, Shapiro J, Amir E, Garg AX, Kim SJ, Wald R. Representation of Patients With Chronic Kidney Disease in Trials of Cancer Therapy. Jama 2018, 319(23):2437-2439.
3. Hasheminejad N, Namdari M, Mahmoodi MR, Bahrampour A, Azmandian J. Association of Handgrip Strength With Malnutrition-Inflammation Score as an Assessment of Nutritional Status in Hemodialysis Patients. Iran J Kidney Dis 2016, 10(1):30-35.
4. Paek J, Choi YJ. Association between hand grip strength and impaired health-related quality of life in Korean cancer survivors: a cross-sectional study. BMJ open 2019, 9(9):e030938.
5. Castro JR, Silva Junior GB, Carvalho AF, et al. Cancer patients under maintenance hemodialysis: relationship between quality of life, depression, sleep quality and malnutrition-inflammation score. Blood Purif 2014, 38(1):46-54.

6. Demiral Y, Ergor G, Unal B, et al. Normative data and discriminative properties of short form 36 (SF-36) in Turkish urban population. BMC Public Health 2006, 6:247.
7. Bilgic A, Akgul A, Sezer S, Arat Z, Ozdemir FN, Haberal M. Nutritional status and depression, sleep disorder, and quality of life in hemodialysis patients. J Ren Nutr 2007, 17(6):381-388.
8. Agargun YM, Kara H, Anlar O. Validity and Reliability of Pittsburg Sleep Quality Index. Turk J Psychiatry 1996, 7:107-111.
9. Buysse DJ, Reynolds CF 3rd, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res 1989, 28(2):193-213.
10. Walters AS. Toward a better definition of the restless legs syndrome. The International Restless Legs Syndrome Study Group. Mov Disorder 1995, 10(5):634-642.
11. Kalantar-Zadeh K, Kopple JD, Block G, Humphreys MH. A malnutrition-inflammation score is correlated with morbidity and mortality in maintenance hemodialysis patients. Am J Kidney Dis 2001, 38(6):1251-1263.
12. Na SY, Sung JY, Chang JH, et al. Chronic Kidney Disease in Cancer Patients: An Independent Predictor of Cancer-Specific Mortality. Am J Nephrol 2011, 33(2):121-130.
13. Bradbury BD, Fissell RB, Albert JM, et al. Predictors of early mortality among incident US hemodialysis patients in the Dialysis Outcomes and Practice Patterns Study (DOPPS). Clin J Am Soc Nephrol 2007, 2(1):89-99.
14. Kaya T, Acar BA, Sipahi S, et al. Relationships Between Malnutrition, Inflammation, Sleep Quality, and Restless Legs Syndrome in Hemodialysis Patients. Ther Apher Dial 2015, 19(5):497-502.
15. Jakobsen LH, Rask IK, Kondrup J. Validation of handgrip strength and endurance as a measure of physical function and quality of life in healthy subjects and patients. Nutrition 2010, 26(5):542-550.
16. Morishita S, Tsubaki A, Shirai N. Physical function was related to mortality in patients with chronic kidney disease and dialysis. Hemodial Int 2017, 21(4):483-489.
17. Morishita S, Tsubaki A, Fu JB, Mitobe Y, Onishi H, Tsuji T. Cancer survivors exhibit a different relationship between muscle strength and health-related quality of life/fatigue compared to healthy subjects. Eur J Cancer Care 2018, 27(4):e12856.
18. Yang L, Koyanagi A, Smith L, et al. Hand grip strength and cognitive function among elderly cancer survivors. PLoS One 2018, 13(6):e0197909.
19. Sabbatini M, Minale B, Crispo A, et al. Insomnia in maintenance haemodialysis patients. Nephrol Dial Transplant 2002, 17(5):852-6.