Chronic bronchiolitis in ankylosing spondylitis

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David Marquette
Elisabeth Diot
Anne de Muret
Olivier Favelle
Alain Sonneville
Saloua Mammou
Pascal Dumont
Patrice Diot
sylvain Marchand-Adam


Ankylosing spondylitis, Bronchiolitis, Dyspnea


The pleuro-pulmonary signs of ankylosing spondylitis are generally asymptomatic, typically represented by biapical lung fibrosis. To our knowledge, the severe bronchiolitis which is sometimes observed in other spondyloarthropathies has not been described in ankylosing spondylitis. We report two cases of severe chronic bronchiolitis in ankylosing spondylitis patients. Their clinical and radiological presentation were similar, characterized by progressive deterioration of stage III-IV dyspnea, non-reversible obstructive ventilatory defect, and CT scan showing air trapping with mosaic attenuation and ground-glass opacity in expiration. Lung biopsies confirmed the diagnosis of severe follicular bronchiolitis in one patient and constrictive bronchiolitis is suspected in the other. Only the patient with follicular bronchiolitis responded positively to treatment with low doses of macrolides
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