Osteoarthritis and degenerative joint disease: local treatment optionsupdate

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B. Palmieri
D. Lodi
S. Capone


Intra-articular injection, hyaluronic acid, glucocorticoids, joint disease, osteoarthritis


This review describes intra-articular drugs therapy of arthritis and degenerative joint disease) with a range of old and recent molecules with specific focus on hyaluronic acid. HA is a cartilage matrix basic component secreted by chondrocytes: it prevents cartilage degradation by a complex interpherence between metalloproteinases, pain mediators and cells. Local injections of HA improve functional activity and pain management, particularly when it is combined with other selected drugs.


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