Vitamin D Deficiency And Insufficiency In Turkish Patients With Breast Cancer

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F. İlknur Kayali
Rahşan Habiboğlu
İrem Sarıcanbaz


vitamin D, cancer, breast cancer, women


Aim: We aimed to reveal vitamin D levels in women with breast cancer.

Patients and Methods: 561 women with primary breast cancer were included in the study. The median age was 55.86 years (between 20 – 78 years). All of the patients were treated with curative intend. None of the patients had metastatic disease.

Results: The median 25(OH)D level was 11.92ng/ml and the mean 25(OH)D level was 13.91ng/ml . Deficiency was detected in 456 patients (81.28%) and insufficiency was detected in 61 patients (10.87 %).

Conclusion:This study points out that vitamin D levels in breast cancer patients should be measured and be corrected whenever diagnosed.

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1- Kennel KA, Drake MT and Hurley DL. (2010). Vitamin D deficiency in adults: when to test and how to treat. Mayo Clinic proceedings, 85(8): 752–758.
2- AcarkanT. (2015). D Vitamini. Bilimsel Tamamlayıcı Tıp, Regülasyon ve Nöralterapi dergisi, 9(3): 5-8.
4- Fidan F, Alkan BM, Tosun A. (2014). Çağın Pandemisi: D Vitamini Eksikliği Ve Yetersizliği. Türk Osteoporoz Dergisi, 20:71-74. 
5- Kennel KA, Drake MT. (2013). Vitamin D in the cancer patient. Current opinion in supportive and palliative care, 7(3): 272–277.
6- Verma A, Cohen DJ, Schwartz N, Muktipaty C, Koblinski JE, Boyan BD, et al. (2019). 24R,25-Dihydroxyvitamin D3 regulates breast cancer cells in vitro and in vivo. Biochimica et biophysica acta. General subjects, 1863(10): 1498–1512.
7- Kanstrup C, Teilum D, Rejnmark L, Bigaard J V, Eiken P, Kroman N, et al. (2020). 25-Hydroxyvitamin D at time of breast cancer diagnosis and breast cancer survival. Breast cancer research and treatment, 179(3): 699–708.
8- Öğüş E, Sürer H, Kılınç AŞ, Fidancı V, Yılmaz G, Dindar N et al. (2015). Evaluation of Vitamin D Levels by Months, Sex and Age. Ankara Med J., 15(1):1-5.
9- Grant WB. (2020). Review of Recent Advances in Understanding the Role of Vitamin D in Reducing Cancer Risk: Breast, Colorectal, Prostate, and Overall Cancer. Anticancer research, 40(1): 491–499.
10- Shamsi U, Khan S, Azam I, Habib Khan A, Maqbool A, Hanif M, Gill T, et al. (2020). A multicenter case control study of association of vitamin D with breast cancer among women in Karachi, Pakistan. PloS one, 15(1), e0225402.
11- Qin B, Xu B, Ji N, Yao S, Pawlish K, Llanos AAM, et al. (2020). Intake of vitamin D and calcium, sun exposure, and risk of breast cancer subtypes among black women. The American Journal of Clinical Nutrition, 111(2), 396-405.
12- Yin L, Grandi N, Raum E, Haug U, Arndt V, Brenner H. (2010). Meta-analysis: serum vitamin D and breast cancer risk. European journal of cancer (Oxford, England: 1990). 46(12): 2196–2205.
13- Vurgun E, Evliyaoğlu O, Yıldırmak S. (2016). Evidence-Based Laboratory: Determining the Insuffciency Level of Vitamin D. Haseki Tıp Bülteni, 54, 76-82.
15- Öksüz A, Kutlu R. (2018). Meram Tıp Fakültesi Hastanesi Aile Hekimliği Polikliniğine Başvuran Hastaların D Vitamini Düzeylerinin Değerlendirilmesi. Konuralp Tıp Dergisi, 10(2): 160-166.
16- Hofmann JN,Yu K, Horst RL, Hayes RB. (2010). Purdue MP: Long-term variation in serum 25-hydroxyvitamin D concentration among participants in the prostate, lung, colorectal, and ovarian cancer screening trial. Cancer Epidemiology, Biomarkers and Prevention, 19(4): 927–931.
17- Kim HB, Myung SK, Lee YJ, Park BJ, Korean Meta-Analysis (KORMA) Study Group. (2018). Efficacy of vitamin D supplementation in combination with conventional antiviral therapy in patients with chronic hepatitis C infection: a meta-analysis of randomised controlled trials. Journal of human nutrition and dietetics : the official journal of the British Dietetic Association,  31(2): 168–177.
18- Ong JS, Cuellar-Partida G, Lu Y, Australian Ovarian Cancer Study, Fasching PA, Hein A, et al. (2016). Association of vitamin D levels and risk of ovarian cancer: a Mendelian randomization study. International journal of epidemiology, 45(5): 1619–1630.
19- Ong JS, Gharahkhani P, An J, Law MH, Whiteman DC, Neale RE et al. (2018). Vitamin D and overall cancer risk and cancer mortality: a Mendelian randomization study. Human molecular genetics, 27(24): 4315–4322.
20- Afzal S, Brondum-Jacobsen P, Bojesen SE, Nordestgaard BG (2014). Genetically low vitamin D concentrations and increased mortality: Mendelian randomisation analysis in three large cohorts. BMJ, 349: g6330.
21- Lagunova Z, Porojnicu AC, Lindberg F, Hexeberg S, Moan J. (2009). The dependency of vitamin D status on body mass index, gender, age and season. Anticancer research, 29(9): 3713–3720.
22- Alpdemir M, Alpdemir MF. (2019). Meta Analysis Vitamin D deficiency status in Turkey: A meta-analysis. Int J Med Biochem, 2(3):118-131.
23- Hekimsoy Z, Dinç G, Kafesçiler S, Onur E, Güvenç Y, Pala T, et al. (2010). Vitamin D status among adults in the Aegean region of Turkey. BMC Public Health, 10(1): 78.