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Gliclazide; Cremophor®RH40; Oral solid lipid formulations; Neusilin®UFL2
Aim of this study was investigation into solid oral lipid formulations with poorly soluble substance gliclazide, using non-ionic surfactant Cremophor®RH40. The use of a new approach to the formulation of type IV of solid oral lipid formulations is described. Drug/surfactant solution was adsorbed on magnesium-aluminium metasilicate (Neusilin®UFL2) carrier with or without addition of superdisintegrant and filled into hard gelatin capsules or compressed into tablets. In this way, a very fast and complete dissolution of poorly soluble drug is achieved. This study shown that with proper selection of ratio of drug/surfactant/adsorbent, with or without superdisintegrant in formulation, it is possible to achieve rapid dissolving of poorly soluble drug from solid dosage forms.
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