Linoleic acid: have we understood how it works in psychopathologies and Ischemic Cardiovascular Diseases?

Main Article Content

Massimo Cocchi
Elisabetta Mondo
Chara Minuto
Giovanni Lercker


linoleic acid, psychopatology, cardiovascular disease, membrane mobility


The question about Linoleic Acid, which remains arguable, is whether the Linoleic Acid is inversely
correlated to the Cardiovascular Disease or not and whether increasing the intake over the Recommended
Daily Allowance (RDA) is positive or negative. The scientific literature, past and recent, is still
controversial about the matter. To try to answer this controversy, it is important to remember the role of the
Linoleic Acid in the membrane and its relationship with cholesterol. Furthermore, it is important to examine
the effect of the oxidation of Linoleic Acid, its impact on the gut microbiota and the consequences on the gut
epithelial integrity.
Highlights. Nutritional considerations about Linoleic Acid > Characteristic of oxidizability of Linoleic Acid
with respect to the cell membrane function > Linoleic Acid in platelets > The position of Linoleic Acid with
respect to Psychopathology and Ischemic Cardiovascular Disease > Linoleic Acid and its effect on gut bacteria
adhesion to gut epithelial barrier.


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