Clinical applications of Gymnema sylvestre against type 2 diabetes mellitus and its associated abnormalities

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Dhananjay Yadav
Minseok Kwak
Jun-O Jin


Diabetes Mellitus, Gymnema sylvestre, Anti-diabetic, Anti-hyperlipidemic, Anti-inflammatory, Anti-Cancerous


Diabetes mellitus (Madhumeha) is one of the leading metabolic disorder prevalent in the developing countries which is characterized by high blood sugar level and is associated with macrovascular and microvascular complications. The Indian Ayurveda describes several herbs for the management and treatment of diabetes mellitus among which Gymnema sylvestre (Asclepiadaceae) is revered as a potential antidiabetic herbal drug which has the capability of simultaneously regenerating β-cell and stimulating insulin secretion. Gymnema sylvestre also possesses anti-obesity, anti-hyperlipidemic, anti-inflammatory, and anti-cancerous activities. This review updates the recent developments in the experimental studies conducted on the Gymnema sylvestre as an effective remedy for diabetes mellitus evidenced by both animals and human studies. Moreover, this study also discussed the toxicity of Gymnema sylvestre and future challenges in the roadmap of formulation for prevention and control of diabetes.

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